Detailed information of TA system TA106347

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 310237..310823
• Replicon: chromosome
• Accession: NZ_CP029682
• Organism: Salmonella sp. FORC89

Toxin (Protein)

• Gene name: doc
• Uniprot ID: A0A3V9X0E4
• Locus tag: FORC89_RS01415
• Protein ID: WP_000174964.1
• Coordinates: 310455..310823 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: V7IU48
• Locus tag: FORC89_RS01410
• Protein ID: WP_001522145.1
• Coordinates: 310237..310458 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC89_RS01385 (305258)	305258..306367	+	1110	WP_000822978.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-
FORC89_RS01390 (306427)	306427..307353	+	927	WP_000003007.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
FORC89_RS01395 (307350)	307350..308627	+	1278	WP_000803764.1	branched chain amino acid ABC transporter permease LivM	-
FORC89_RS01400 (308624)	308624..309391	+	768	WP_000082080.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
FORC89_RS01405 (309393)	309393..310106	+	714	WP_000416114.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
FORC89_RS01410 (310237)	310237..310458	+	222	WP_001522145.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FORC89_RS01415 (310455)	310455..310823	+	369	WP_000174964.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
FORC89_RS01420 (311082)	311082..312398	+	1317	WP_000624755.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
FORC89_RS01425 (312503)	312503..313390	+	888	WP_000099303.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
FORC89_RS01430 (313387)	313387..314232	+	846	WP_000572196.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
FORC89_RS01435 (314234)	314234..315304	+	1071	WP_000907840.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	307350..316041	8691

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (6-114)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-49)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13601.91 Da
• Isoelectric Point: 6.7252

>T106347 WP_000174964.1 NZ_CP029682:310455-310823 [Salmonella sp. FORC89]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIVVRLRA

Nucleotide

• Length: 369 bp

>T106347 NZ_CP029682:310455-310823 [Salmonella sp. FORC89]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8166.17 Da
• Isoelectric Point: 5.0775

>AT106347 WP_001522145.1 NZ_CP029682:310237-310458 [Salmonella sp. FORC89]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Nucleotide

• Length: 222 bp

>AT106347 NZ_CP029682:310237-310458 [Salmonella sp. FORC89]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A3V9X0E4