Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 1998841..1999370 Replicon chromosome
Accession NZ_CP029681
Organism Staphylococcus aureus strain AR_0473

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag CSC58_RS10610 Protein ID WP_001103933.1
Coordinates 1998841..1999158 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A2X2M557
Locus tag CSC58_RS10615 Protein ID WP_001058488.1
Coordinates 1999161..1999370 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC58_RS10585 1993956..1994297 - 342 WP_001190614.1 hypothetical protein -
CSC58_RS10590 1994833..1995474 - 642 WP_064140196.1 pathogenicity island protein -
CSC58_RS10595 1995471..1995851 - 381 WP_000356927.1 hypothetical protein -
CSC58_RS10600 1996182..1997891 - 1710 WP_000447454.1 DUF927 domain-containing protein -
CSC58_RS10605 1997905..1998774 - 870 WP_001002701.1 primase alpha helix C-terminal domain-containing protein -
CSC58_RS10610 1998841..1999158 - 318 WP_001103933.1 DUF1474 family protein Toxin
CSC58_RS10615 1999161..1999370 - 210 WP_001058488.1 hypothetical protein Antitoxin
CSC58_RS14835 1999363..1999509 - 147 WP_181819064.1 hypothetical protein -
CSC58_RS10620 1999556..1999816 - 261 WP_001147662.1 hypothetical protein -
CSC58_RS10625 1999818..2000015 - 198 WP_000466891.1 helix-turn-helix transcriptional regulator -
CSC58_RS10630 2000159..2000782 + 624 WP_000431539.1 helix-turn-helix domain-containing protein -
CSC58_RS10635 2000878..2002014 + 1137 WP_000592973.1 site-specific integrase -
CSC58_RS10640 2002108..2003649 - 1542 WP_000424963.1 glutamine-hydrolyzing GMP synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sell / sec 1981272..2006446 25174


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T106341 WP_001103933.1 NZ_CP029681:c1999158-1998841 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T106341 NZ_CP029681:c1999158-1998841 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTGATGTGTGATATTGAAGTGATAAAAGAAAAAATCAATGATGTAGCTATCAAACATGG
TTGGTTTGTTGAAGATAAATTTGTCAAAAATGAATTAGAAACAAAACAGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8287.31 Da        Isoelectric Point: 4.2820

>AT106341 WP_001058488.1 NZ_CP029681:c1999370-1999161 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT106341 NZ_CP029681:c1999370-1999161 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTATCATGAATAATTTTGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAAAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2M557

References