Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1552840..1553317 Replicon chromosome
Accession NZ_CP029681
Organism Staphylococcus aureus strain AR_0473

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CSC58_RS08310 Protein ID WP_000052076.1
Coordinates 1553129..1553317 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CSC58_RS08305 Protein ID WP_001059690.1
Coordinates 1552840..1553100 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC58_RS08270 1548232..1548948 - 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -
CSC58_RS08275 1549096..1549518 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
CSC58_RS08280 1549917..1550411 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
CSC58_RS08285 1550567..1551184 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
CSC58_RS08290 1551257..1551838 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
CSC58_RS08295 1552063..1552299 + 237 WP_000368687.1 hypothetical protein -
CSC58_RS08300 1552296..1552499 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CSC58_RS08305 1552840..1553100 + 261 WP_001059690.1 hypothetical protein Antitoxin
CSC58_RS08310 1553129..1553317 + 189 WP_000052076.1 hypothetical protein Toxin
CSC58_RS08315 1553505..1554074 + 570 WP_001106654.1 hypothetical protein -
CSC58_RS08320 1554162..1554446 + 285 WP_001004395.1 hypothetical protein -
CSC58_RS08325 1554508..1554726 + 219 WP_000005886.1 hypothetical protein -
CSC58_RS08330 1555222..1555422 - 201 WP_001059082.1 cold-shock protein -
CSC58_RS08335 1555779..1556465 - 687 WP_001792695.1 thermonuclease family protein -
CSC58_RS08340 1556806..1557327 - 522 WP_000824484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T106340 WP_000052076.1 NZ_CP029681:1553129-1553317 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T106340 NZ_CP029681:1553129-1553317 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT106340 WP_001059690.1 NZ_CP029681:1552840-1553100 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT106340 NZ_CP029681:1552840-1553100 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References