Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1682881..1683358 Replicon chromosome
Accession NZ_CP029680
Organism Staphylococcus aureus strain AR_0215

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CSB71_RS09420 Protein ID WP_000052076.1
Coordinates 1683170..1683358 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CSB71_RS09415 Protein ID WP_001059690.1
Coordinates 1682881..1683141 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB71_RS09380 1678275..1678991 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
CSB71_RS09385 1679138..1679560 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
CSB71_RS09390 1679959..1680453 + 495 WP_000569883.1 GNAT family N-acetyltransferase -
CSB71_RS09395 1680608..1681225 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
CSB71_RS09400 1681298..1681879 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
CSB71_RS09405 1682104..1682340 + 237 WP_000349581.1 hypothetical protein -
CSB71_RS09410 1682337..1682540 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CSB71_RS09415 1682881..1683141 + 261 WP_001059690.1 hypothetical protein Antitoxin
CSB71_RS09420 1683170..1683358 + 189 WP_000052076.1 hypothetical protein Toxin
CSB71_RS09425 1683546..1684115 + 570 WP_001106658.1 hypothetical protein -
CSB71_RS09430 1684203..1684472 + 270 WP_001004398.1 hypothetical protein -
CSB71_RS09435 1684549..1684767 + 219 WP_000005886.1 hypothetical protein -
CSB71_RS09440 1685259..1685459 - 201 WP_001059082.1 cold-shock protein -
CSB71_RS09445 1685816..1686502 - 687 WP_000141557.1 thermonuclease family protein -
CSB71_RS09450 1686843..1687364 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T106320 WP_000052076.1 NZ_CP029680:1683170-1683358 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T106320 NZ_CP029680:1683170-1683358 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT106320 WP_001059690.1 NZ_CP029680:1682881-1683141 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT106320 NZ_CP029680:1682881-1683141 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References