106286

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 887187..887664 Replicon chromosome
Accession NZ_CP029678
Organism Staphylococcus aureus strain AR_0216

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag CSB72_RS04680 Protein ID WP_000052078.1
Coordinates 887187..887375 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CSB72_RS04685 Protein ID WP_001059690.1
Coordinates 887404..887664 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB72_RS04650 883228..883698 + 471 WP_000824472.1 hypothetical protein -
CSB72_RS04655 884039..884725 + 687 WP_001548082.1 thermonuclease family protein -
CSB72_RS04660 885082..885282 + 201 WP_001059082.1 cold-shock protein -
CSB72_RS04665 885778..885996 - 219 WP_000005886.1 hypothetical protein -
CSB72_RS04670 886058..886342 - 285 WP_001004395.1 hypothetical protein -
CSB72_RS04675 886430..886999 - 570 WP_001106654.1 hypothetical protein -
CSB72_RS04680 887187..887375 - 189 WP_000052078.1 hypothetical protein Toxin
CSB72_RS04685 887404..887664 - 261 WP_001059690.1 hypothetical protein Antitoxin
CSB72_RS04690 888005..888208 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CSB72_RS04695 888205..888441 - 237 WP_000368687.1 hypothetical protein -
CSB72_RS04700 888666..889247 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
CSB72_RS04705 889320..889937 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
CSB72_RS04710 890092..890586 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
CSB72_RS04715 890985..891407 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
CSB72_RS04720 891555..892271 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 881871..964377 82506


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T106286 WP_000052078.1 NZ_CP029678:c887375-887187 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T106286 NZ_CP029678:c887375-887187 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT106286 WP_001059690.1 NZ_CP029678:c887664-887404 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT106286 NZ_CP029678:c887664-887404 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References