Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2144865..2145403 Replicon chromosome
Accession NZ_CP029675
Organism Staphylococcus aureus strain AR_0219

Toxin (Protein)


Gene name TscT Uniprot ID A0A0H3K0C1
Locus tag CSB75_RS11385 Protein ID WP_001078344.1
Coordinates 2144865..2145191 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A0H3JSN0
Locus tag CSB75_RS11390 Protein ID WP_001058495.1
Coordinates 2145194..2145403 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB75_RS11360 2140090..2140430 - 341 Protein_2069 pathogenicity island protein -
CSB75_RS11365 2140880..2141521 - 642 WP_001047698.1 hypothetical protein -
CSB75_RS11370 2141518..2141898 - 381 WP_000356942.1 hypothetical protein -
CSB75_RS11375 2142208..2143917 - 1710 WP_000447473.1 DUF927 domain-containing protein -
CSB75_RS11380 2143931..2144800 - 870 WP_001002689.1 primase alpha helix C-terminal domain-containing protein -
CSB75_RS11385 2144865..2145191 - 327 WP_001078344.1 DUF1474 family protein Toxin
CSB75_RS11390 2145194..2145403 - 210 WP_001058495.1 hypothetical protein Antitoxin
CSB75_RS11395 2145396..2145542 - 147 WP_000784885.1 hypothetical protein -
CSB75_RS11400 2145539..2145856 - 318 WP_000481967.1 helix-turn-helix domain-containing protein -
CSB75_RS11405 2145861..2146079 - 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
CSB75_RS11410 2146252..2146926 + 675 WP_000620857.1 helix-turn-helix transcriptional regulator -
CSB75_RS11415 2146940..2148112 + 1173 WP_000179343.1 site-specific integrase -
CSB75_RS11420 2148181..2149797 - 1617 WP_000240642.1 chaperonin GroEL -
CSB75_RS11425 2149873..2150157 - 285 WP_000917289.1 co-chaperone GroES -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / sak / sea / hlb / sell / sec / tsst-1 / groEL 2083726..2150157 66431


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12968.26 Da        Isoelectric Point: 4.3050

>T106277 WP_001078344.1 NZ_CP029675:c2145191-2144865 [Staphylococcus aureus]
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE

Download         Length: 327 bp

>T106277 NZ_CP029675:c2145191-2144865 [Staphylococcus aureus]
ATGAATCGGGAAATTAAAGATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAGTAATGG
TTGGCATTTTGATGAGCTATATCCATATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGC
AGAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8206.22 Da        Isoelectric Point: 4.3718

>AT106277 WP_001058495.1 NZ_CP029675:c2145403-2145194 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVVNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT106277 NZ_CP029675:c2145403-2145194 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCGTGAATAATTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3K0C1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3JSN0

References