106270

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 896879..897356 Replicon chromosome
Accession NZ_CP029675
Organism Staphylococcus aureus strain AR_0219

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CSB75_RS04680 Protein ID WP_000052076.1
Coordinates 896879..897067 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CSB75_RS04685 Protein ID WP_001059690.1
Coordinates 897096..897356 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB75_RS04650 892873..893394 + 522 WP_000824482.1 hypothetical protein -
CSB75_RS04655 893735..894421 + 687 WP_000141557.1 thermonuclease family protein -
CSB75_RS04660 894778..894978 + 201 WP_001059082.1 cold-shock protein -
CSB75_RS04665 895470..895688 - 219 WP_000005886.1 hypothetical protein -
CSB75_RS04670 895750..896034 - 285 WP_001004399.1 hypothetical protein -
CSB75_RS04675 896122..896691 - 570 WP_001106654.1 hypothetical protein -
CSB75_RS04680 896879..897067 - 189 WP_000052076.1 hypothetical protein Toxin
CSB75_RS04685 897096..897356 - 261 WP_001059690.1 hypothetical protein Antitoxin
CSB75_RS04690 897697..897900 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CSB75_RS04695 897897..898133 - 237 WP_000349581.1 hypothetical protein -
CSB75_RS04700 898358..898939 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
CSB75_RS04705 899012..899629 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
CSB75_RS04710 899784..900278 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
CSB75_RS04715 900677..901099 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
CSB75_RS04720 901247..901963 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Toxin HigB-like

(13-91)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T106270 WP_000052076.1 NZ_CP029675:c897067-896879 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T106270 NZ_CP029675:c897067-896879 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT106270 WP_001059690.1 NZ_CP029675:c897356-897096 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT106270 NZ_CP029675:c897356-897096 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References