Detailed information of TA system TA106261

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2149781..2150310
• Replicon: chromosome
• Accession: NZ_CP029673
• Organism: Staphylococcus aureus strain AR_0220

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: CSB76_RS11260
• Protein ID: WP_000621175.1
• Coordinates: 2149781..2150143 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: CSB76_RS11265
• Protein ID: WP_000948331.1
• Coordinates: 2150140..2150310 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSB76_RS11235	2146759..2147529	-	771	WP_001041111.1	RNA polymerase sigma factor SigB	-
CSB76_RS11240	2147504..2147983	-	480	WP_001190829.1	anti-sigma B factor RsbW	-
CSB76_RS11245	2147985..2148311	-	327	WP_001052491.1	anti-sigma factor antagonist	-
CSB76_RS11250	2148430..2149431	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
CSB76_RS11260	2149781..2150143	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
CSB76_RS11265	2150140..2150310	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
CSB76_RS11270	2150395..2151543	-	1149	WP_001281154.1	alanine racemase	-
CSB76_RS11275	2151609..2151968	-	360	WP_000581197.1	holo-ACP synthase	-
CSB76_RS11280	2151972..2152463	-	492	WP_001205912.1	PH domain-containing protein	-
CSB76_RS11285	2152450..2154032	-	1583	Protein_2049	PH domain-containing protein	-
CSB76_RS11290	2154025..2154504	-	480	WP_001287087.1	hypothetical protein	-
CSB76_RS11295	2154712..2155272	-	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T106261 WP_000621175.1 NZ_CP029673:c2150143-2149781 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T106261 NZ_CP029673:c2150143-2149781 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT106261 WP_000948331.1 NZ_CP029673:c2150310-2150140 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT106261 NZ_CP029673:c2150310-2150140 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1