Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 863418..863895 Replicon chromosome
Accession NZ_CP029673
Organism Staphylococcus aureus strain AR_0220

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CSB76_RS04425 Protein ID WP_000052076.1
Coordinates 863418..863606 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CSB76_RS04430 Protein ID WP_001059690.1
Coordinates 863635..863895 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB76_RS04395 859412..859933 + 522 WP_000824482.1 hypothetical protein -
CSB76_RS04400 860274..860960 + 687 WP_000141557.1 thermonuclease family protein -
CSB76_RS04405 861317..861517 + 201 WP_001059082.1 cold-shock protein -
CSB76_RS04410 862009..862227 - 219 WP_000005886.1 hypothetical protein -
CSB76_RS04415 862289..862573 - 285 WP_001004399.1 hypothetical protein -
CSB76_RS04420 862661..863230 - 570 WP_001106658.1 hypothetical protein -
CSB76_RS04425 863418..863606 - 189 WP_000052076.1 hypothetical protein Toxin
CSB76_RS04430 863635..863895 - 261 WP_001059690.1 hypothetical protein Antitoxin
CSB76_RS04435 864236..864439 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CSB76_RS04440 864436..864672 - 237 WP_000349581.1 hypothetical protein -
CSB76_RS04445 864897..865478 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
CSB76_RS04450 865551..866168 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
CSB76_RS04455 866323..866817 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
CSB76_RS04460 867216..867638 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
CSB76_RS04465 867786..868502 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T106254 WP_000052076.1 NZ_CP029673:c863606-863418 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T106254 NZ_CP029673:c863606-863418 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT106254 WP_001059690.1 NZ_CP029673:c863895-863635 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT106254 NZ_CP029673:c863895-863635 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References