Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 863418..863895 Replicon chromosome
Accession NZ_CP029673
Organism Staphylococcus aureus strain AR_0220

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CSB76_RS04425 Protein ID WP_000052076.1
Coordinates 863418..863606 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CSB76_RS04430 Protein ID WP_001059690.1
Coordinates 863635..863895 (-) Length 87 a.a.

Genomic Context

CSB76_RS04395CSB76_RS04400CSB76_RS04405CSB76_RS04435CSB76_RS04445CSB76_RS04465CSB76_RS04410CSB76_RS04415CSB76_RS04420CSB76_RS04425CSB76_RS04430CSB76_RS04440CSB76_RS04450CSB76_RS04455CSB76_RS04460
Location: 859412..859933 (522 bp)
Type: Others
Protein ID: WP_000824482.1
Location: 860274..860960 (687 bp)
Type: Others
Protein ID: WP_000141557.1
Location: 861317..861517 (201 bp)
Type: Others
Protein ID: WP_001059082.1
Location: 864236..864439 (204 bp)
Type: Others
Protein ID: WP_000145163.1
Location: 864897..865478 (582 bp)
Type: Others
Protein ID: WP_001140693.1
Location: 867786..868502 (717 bp)
Type: Others
Protein ID: WP_000150011.1
Location: 862009..862227 (219 bp)
Type: Others
Protein ID: WP_000005886.1
Location: 862289..862573 (285 bp)
Type: Others
Protein ID: WP_001004399.1
Location: 862661..863230 (570 bp)
Type: Others
Protein ID: WP_001106658.1
Location: 863418..863606 (189 bp)
Type: Toxin
Protein ID: WP_000052076.1
Location: 863635..863895 (261 bp)
Type: Antitoxin
Protein ID: WP_001059690.1
Location: 864436..864672 (237 bp)
Type: Others
Protein ID: WP_000349581.1
Location: 865551..866168 (618 bp)
Type: Others
Protein ID: WP_000255551.1
Location: 866323..866817 (495 bp)
Type: Others
Protein ID: WP_000569884.1
Location: 867216..867638 (423 bp)
Type: Others
Protein ID: WP_000974460.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CSB76_RS04395859412..859933+522WP_000824482.1hypothetical protein-
CSB76_RS04400860274..860960+687WP_000141557.1thermonuclease family protein-
CSB76_RS04405861317..861517+201WP_001059082.1cold-shock protein-
CSB76_RS04410862009..862227-219WP_000005886.1hypothetical protein-
CSB76_RS04415862289..862573-285WP_001004399.1hypothetical protein-
CSB76_RS04420862661..863230-570WP_001106658.1hypothetical protein-
CSB76_RS04425863418..863606-189WP_000052076.1hypothetical proteinToxin
CSB76_RS04430863635..863895-261WP_001059690.1hypothetical proteinAntitoxin
CSB76_RS04435864236..864439+204WP_000145163.1sterile alpha motif-like domain-containing protein-
CSB76_RS04440864436..864672-237WP_000349581.1hypothetical protein-
CSB76_RS04445864897..865478+582WP_001140693.1phosphoglycerate mutase family protein-
CSB76_RS04450865551..866168-618WP_000255551.1LysE/ArgO family amino acid transporter-
CSB76_RS04455866323..866817-495WP_000569884.1GNAT family N-acetyltransferase-
CSB76_RS04460867216..867638-423WP_000974460.1organic hydroperoxide resistance protein-
CSB76_RS04465867786..868502+717WP_000150011.1type I 3-dehydroquinate dehydratase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T106254 WP_000052076.1 NZ_CP029673:c863606-863418 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T106254 NZ_CP029673:c863606-863418 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT106254 WP_001059690.1 NZ_CP029673:c863895-863635 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT106254 NZ_CP029673:c863895-863635 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E0VP18

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E0VN56

References