Detailed information of TA system TA106240

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 632204..632733
• Replicon: chromosome
• Accession: NZ_CP029671
• Organism: Staphylococcus aureus strain AR_0222

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: CSB78_RS03280
• Protein ID: WP_110411425.1
• Coordinates: 632204..632521 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IA75
• Locus tag: CSB78_RS03285
• Protein ID: WP_001058492.1
• Coordinates: 632524..632733 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSB78_RS03255	627362..627703	-	342	WP_031885615.1	hypothetical protein	-
CSB78_RS03260	628220..628861	-	642	Protein_584	pathogenicity island protein	-
CSB78_RS03265	628858..629238	-	381	WP_110411419.1	hypothetical protein	-
CSB78_RS03270	629548..631257	-	1710	WP_110411421.1	DUF927 domain-containing protein	-
CSB78_RS03275	631271..632140	-	870	WP_110411423.1	primase alpha helix C-terminal domain-containing protein	-
CSB78_RS03280	632204..632521	-	318	WP_110411425.1	DUF1474 family protein	Toxin
CSB78_RS03285	632524..632733	-	210	WP_001058492.1	hypothetical protein	Antitoxin
CSB78_RS03290	632726..632872	-	147	WP_000784885.1	hypothetical protein	-
CSB78_RS03295	632884..633102	-	219	WP_000163544.1	helix-turn-helix domain-containing protein	-
CSB78_RS03300	633138..633341	-	204	WP_001045296.1	transcriptional regulator	-
CSB78_RS03305	633477..634280	+	804	WP_000358990.1	helix-turn-helix domain-containing protein	-
CSB78_RS03310	634270..635376	+	1107	WP_106699245.1	site-specific integrase	-
CSB78_RS03320	635939..636403	-	465	WP_001085183.1	SsrA-binding protein SmpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp / sell / sec	601365..635376	34011

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12581.19 Da
• Isoelectric Point: 5.0161

>T106240 WP_110411425.1 NZ_CP029671:c632521-632204 [Staphylococcus aureus]
MNWEFKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFGELIQKF
HEIEKASSENFGEVSDDAQKLKITE

Nucleotide

• Length: 318 bp

>T106240 NZ_CP029671:c632521-632204 [Staphylococcus aureus]
ATGAATTGGGAATTTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGTATCAGATGACGCACAAAAATTAAAAATCACAGAGTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8238.28 Da
• Isoelectric Point: 4.3718

>AT106240 WP_001058492.1 NZ_CP029671:c632733-632524 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT106240 NZ_CP029671:c632733-632524 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Antitoxin

• AlphaFold DB: X5IA75