106239

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 604287..604764 Replicon chromosome
Accession NZ_CP029671
Organism Staphylococcus aureus strain AR_0222

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CSB78_RS03120 Protein ID WP_000052076.1
Coordinates 604576..604764 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CSB78_RS03115 Protein ID WP_001059690.1
Coordinates 604287..604547 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB78_RS03080 599680..600396 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
CSB78_RS03085 600544..600966 + 423 WP_033863313.1 organic hydroperoxide resistance protein -
CSB78_RS03090 601365..601859 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
CSB78_RS03095 602014..602631 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
CSB78_RS03100 602704..603285 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
CSB78_RS03105 603510..603746 + 237 WP_000349581.1 hypothetical protein -
CSB78_RS03110 603743..603946 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CSB78_RS03115 604287..604547 + 261 WP_001059690.1 hypothetical protein Antitoxin
CSB78_RS03120 604576..604764 + 189 WP_000052076.1 hypothetical protein Toxin
CSB78_RS03125 604952..605521 + 570 WP_001106654.1 hypothetical protein -
CSB78_RS03130 605609..605893 + 285 WP_001004399.1 hypothetical protein -
CSB78_RS03135 605955..606173 + 219 WP_000005886.1 hypothetical protein -
CSB78_RS03140 606665..606865 - 201 WP_001059082.1 cold-shock protein -
CSB78_RS03145 607222..607908 - 687 WP_000141557.1 thermonuclease family protein -
CSB78_RS03150 608249..608770 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp / sell / sec 601365..635376 34011


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T106239 WP_000052076.1 NZ_CP029671:604576-604764 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T106239 NZ_CP029671:604576-604764 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT106239 WP_001059690.1 NZ_CP029671:604287-604547 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT106239 NZ_CP029671:604287-604547 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References