Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1315124..1315601 Replicon chromosome
Accession NZ_CP029669
Organism Staphylococcus aureus strain AR_0223

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag CSB79_RS07030 Protein ID WP_000052078.1
Coordinates 1315413..1315601 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CSB79_RS07025 Protein ID WP_001059690.1
Coordinates 1315124..1315384 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB79_RS06990 1310517..1311233 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
CSB79_RS06995 1311381..1311803 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
CSB79_RS07000 1312202..1312696 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
CSB79_RS07005 1312851..1313468 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
CSB79_RS07010 1313541..1314122 - 582 WP_001140686.1 phosphoglycerate mutase family protein -
CSB79_RS07015 1314347..1314583 + 237 WP_000368687.1 hypothetical protein -
CSB79_RS07020 1314580..1314783 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CSB79_RS07025 1315124..1315384 + 261 WP_001059690.1 hypothetical protein Antitoxin
CSB79_RS07030 1315413..1315601 + 189 WP_000052078.1 hypothetical protein Toxin
CSB79_RS07035 1315789..1316358 + 570 WP_001106654.1 hypothetical protein -
CSB79_RS07040 1316446..1316730 + 285 WP_001004395.1 hypothetical protein -
CSB79_RS07045 1316792..1317010 + 219 WP_000005886.1 hypothetical protein -
CSB79_RS07050 1317506..1317706 - 201 WP_001059082.1 cold-shock protein -
CSB79_RS07055 1318063..1318749 - 687 WP_001548082.1 thermonuclease family protein -
CSB79_RS07060 1319090..1319560 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selq / selk / vWbp 1289835..1329273 39438


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T106226 WP_000052078.1 NZ_CP029669:1315413-1315601 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T106226 NZ_CP029669:1315413-1315601 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT106226 WP_001059690.1 NZ_CP029669:1315124-1315384 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT106226 NZ_CP029669:1315124-1315384 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References