106217

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1948747..1949224 Replicon chromosome
Accession NZ_CP029667
Organism Staphylococcus aureus strain AR_0225

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag CSB81_RS10690 Protein ID WP_000052078.1
Coordinates 1949036..1949224 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CSB81_RS10685 Protein ID WP_001059690.1
Coordinates 1948747..1949007 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB81_RS10650 1944140..1944856 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
CSB81_RS10655 1945004..1945426 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
CSB81_RS10660 1945825..1946319 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
CSB81_RS10665 1946474..1947091 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
CSB81_RS10670 1947164..1947745 - 582 WP_001140686.1 phosphoglycerate mutase family protein -
CSB81_RS10675 1947970..1948206 + 237 WP_000368687.1 hypothetical protein -
CSB81_RS10680 1948203..1948406 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CSB81_RS10685 1948747..1949007 + 261 WP_001059690.1 hypothetical protein Antitoxin
CSB81_RS10690 1949036..1949224 + 189 WP_000052078.1 hypothetical protein Toxin
CSB81_RS10695 1949412..1949981 + 570 WP_001106654.1 hypothetical protein -
CSB81_RS10700 1950069..1950353 + 285 WP_001004395.1 hypothetical protein -
CSB81_RS10705 1950415..1950633 + 219 WP_000005886.1 hypothetical protein -
CSB81_RS10710 1951129..1951329 - 201 WP_001059082.1 cold-shock protein -
CSB81_RS10715 1951686..1952372 - 687 WP_001548082.1 thermonuclease family protein -
CSB81_RS10720 1952713..1953183 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T106217 WP_000052078.1 NZ_CP029667:1949036-1949224 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T106217 NZ_CP029667:1949036-1949224 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT106217 WP_001059690.1 NZ_CP029667:1948747-1949007 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT106217 NZ_CP029667:1948747-1949007 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References