106200

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1815973..1816450 Replicon chromosome
Accession NZ_CP029664
Organism Staphylococcus aureus strain AR_0226

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag CSB82_RS09775 Protein ID WP_000052078.1
Coordinates 1816262..1816450 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CSB82_RS09770 Protein ID WP_001059690.1
Coordinates 1815973..1816233 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB82_RS09735 1811366..1812082 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
CSB82_RS09740 1812230..1812652 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
CSB82_RS09745 1813051..1813545 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
CSB82_RS09750 1813700..1814317 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
CSB82_RS09755 1814390..1814971 - 582 WP_001140686.1 phosphoglycerate mutase family protein -
CSB82_RS09760 1815196..1815432 + 237 WP_000368687.1 hypothetical protein -
CSB82_RS09765 1815429..1815632 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CSB82_RS09770 1815973..1816233 + 261 WP_001059690.1 hypothetical protein Antitoxin
CSB82_RS09775 1816262..1816450 + 189 WP_000052078.1 hypothetical protein Toxin
CSB82_RS09780 1816638..1817207 + 570 WP_001106654.1 hypothetical protein -
CSB82_RS09785 1817295..1817579 + 285 WP_001004395.1 hypothetical protein -
CSB82_RS09790 1817641..1817859 + 219 WP_000005886.1 hypothetical protein -
CSB82_RS09795 1818355..1818555 - 201 WP_001059082.1 cold-shock protein -
CSB82_RS09800 1818912..1819598 - 687 WP_001548082.1 thermonuclease family protein -
CSB82_RS09805 1819939..1820409 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selq / selk / vWbp 1790685..1830122 39437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T106200 WP_000052078.1 NZ_CP029664:1816262-1816450 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T106200 NZ_CP029664:1816262-1816450 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT106200 WP_001059690.1 NZ_CP029664:1815973-1816233 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT106200 NZ_CP029664:1815973-1816233 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References