Detailed information of TA system TA106193

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 509287..509816
• Replicon: chromosome
• Accession: NZ_CP029664
• Organism: Staphylococcus aureus strain AR_0226

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: CSB82_RS02750
• Protein ID: WP_000621175.1
• Coordinates: 509454..509816 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: CSB82_RS02745
• Protein ID: WP_000948331.1
• Coordinates: 509287..509457 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSB82_RS02715	504324..504884	+	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-
CSB82_RS02720	505092..505571	+	480	WP_001287088.1	hypothetical protein	-
CSB82_RS02725	505564..507147	+	1584	WP_001294626.1	PH domain-containing protein	-
CSB82_RS02730	507134..507625	+	492	WP_001205910.1	PH domain-containing protein	-
CSB82_RS02735	507629..507988	+	360	WP_000581200.1	holo-ACP synthase	-
CSB82_RS02740	508054..509202	+	1149	WP_001281145.1	alanine racemase	-
CSB82_RS02745	509287..509457	+	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
CSB82_RS02750	509454..509816	+	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
CSB82_RS02760	510166..511167	+	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
CSB82_RS02765	511286..511612	+	327	WP_001052491.1	anti-sigma factor antagonist	-
CSB82_RS02770	511614..512093	+	480	WP_001190829.1	anti-sigma B factor RsbW	-
CSB82_RS02775	512068..512838	+	771	WP_001041103.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T106193 WP_000621175.1 NZ_CP029664:509454-509816 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T106193 NZ_CP029664:509454-509816 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT106193 WP_000948331.1 NZ_CP029664:509287-509457 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT106193 NZ_CP029664:509287-509457 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1