Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 861563..862040 Replicon chromosome
Accession NZ_CP029663
Organism Staphylococcus aureus strain AR_0228

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CSB84_RS04530 Protein ID WP_000052076.1
Coordinates 861563..861751 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CSB84_RS04535 Protein ID WP_001059690.1
Coordinates 861780..862040 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB84_RS04500 857557..858078 + 522 WP_000824482.1 hypothetical protein -
CSB84_RS04505 858419..859105 + 687 WP_000141557.1 thermonuclease family protein -
CSB84_RS04510 859462..859662 + 201 WP_001059082.1 cold-shock protein -
CSB84_RS04515 860154..860372 - 219 WP_000005886.1 hypothetical protein -
CSB84_RS04520 860449..860718 - 270 WP_001004398.1 hypothetical protein -
CSB84_RS04525 860806..861375 - 570 WP_001106658.1 hypothetical protein -
CSB84_RS04530 861563..861751 - 189 WP_000052076.1 hypothetical protein Toxin
CSB84_RS04535 861780..862040 - 261 WP_001059690.1 hypothetical protein Antitoxin
CSB84_RS04540 862381..862584 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CSB84_RS04545 862581..862817 - 237 WP_000349581.1 hypothetical protein -
CSB84_RS04550 863042..863623 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
CSB84_RS04555 863696..864313 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
CSB84_RS04560 864468..864962 - 495 WP_000569883.1 GNAT family N-acetyltransferase -
CSB84_RS04565 865361..865783 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
CSB84_RS04570 865931..866647 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T106169 WP_000052076.1 NZ_CP029663:c861751-861563 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T106169 NZ_CP029663:c861751-861563 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT106169 WP_001059690.1 NZ_CP029663:c862040-861780 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT106169 NZ_CP029663:c862040-861780 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References