Detailed information of TA system TA106168

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 5293601..5294106
• Replicon: chromosome
• Accession: NZ_CP029660
• Organism: Pseudomonas aeruginosa strain AR_0446

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: CSC33_RS25210
• Protein ID: WP_033968140.1
• Coordinates: 5293601..5293882 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: CSC33_RS25215
• Protein ID: WP_003083775.1
• Coordinates: 5293879..5294106 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC33_RS25185	5288851..5290200	+	1350	WP_073648652.1	C4-dicarboxylate transporter DctA	-
CSC33_RS25190	5290250..5290936	+	687	WP_003083762.1	FadR family transcriptional regulator	-
CSC33_RS25195	5291037..5291771	+	735	WP_003117208.1	GntR family transcriptional regulator	-
CSC33_RS25200	5291975..5292361	+	387	WP_003083767.1	aegerolysin family protein	-
CSC33_RS25205	5292393..5293301	-	909	WP_033977366.1	LysR family transcriptional regulator	-
CSC33_RS25210	5293601..5293882	-	282	WP_033968140.1	type II toxin-antitoxin system toxin ParE	Toxin
CSC33_RS25215	5293879..5294106	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
CSC33_RS25220	5294282..5294902	-	621	WP_033968139.1	hypothetical protein	-
CSC33_RS25225	5295003..5295503	+	501	WP_003101228.1	LEA type 2 family protein	-
CSC33_RS25230	5295576..5295917	+	342	WP_003101229.1	alkylphosphonate utilization protein	-
CSC33_RS25235	5296001..5297428	-	1428	WP_003083784.1	GABA permease	-
CSC33_RS25240	5297597..5299090	-	1494	WP_023115963.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10429.16 Da
• Isoelectric Point: 9.6558

>T106168 WP_033968140.1 NZ_CP029660:c5293882-5293601 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQEVANQGAGRPSEVPGVRTLPLERWPFSAPFRVKGKE
IQILRIDRVEIAP

Nucleotide

• Length: 282 bp

>T106168 NZ_CP029660:c5293882-5293601 [Pseudomonas aeruginosa]
ATGAGCCTGAAATGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTATGACCATTACGTCGTGCTGATCGGCCCGGA
GAAAGCGCTGAAAGCCGTGCAGGACATCGTCGAGCAGGTGAAGCCGCTGCAGGAGGTAGCCAACCAGGGGGCAGGGCGAC
CCAGCGAGGTACCAGGCGTACGCACCCTGCCCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTGGAAATTGCCCCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT106168 WP_003083775.1 NZ_CP029660:c5294106-5293879 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT106168 NZ_CP029660:c5294106-5293879 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGCCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1C7BDS9