Detailed information of TA system TA106166

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 3207424..3208682
• Replicon: chromosome
• Accession: NZ_CP029660
• Organism: Pseudomonas aeruginosa strain AR_0446

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A6A9JV85
• Locus tag: CSC33_RS15265
• Protein ID: WP_033969419.1
• Coordinates: 3207424..3208179 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: CSC33_RS15270
• Protein ID: WP_003086329.1
• Coordinates: 3208314..3208682 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC33_RS15255	3202593..3205136	+	2544	WP_110194221.1	acyl-homoserine-lactone acylase QuiP	-
CSC33_RS15260	3205291..3206652	-	1362	WP_003134034.1	DNA recombination protein RmuC	-
CSC33_RS15265	3207424..3208179	-	756	WP_033969419.1	RES family NAD+ phosphorylase	Toxin
CSC33_RS15270	3208314..3208682	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
CSC33_RS15275	3208755..3210041	-	1287	WP_110194222.1	FAD-binding oxidoreductase	-
CSC33_RS15280	3210095..3211684	-	1590	WP_162601963.1	aldehyde dehydrogenase family protein	-
CSC33_RS15285	3211762..3212238	+	477	WP_033976822.1	hypothetical protein	-
CSC33_RS31315	3212241..3212516	-	276	WP_180737616.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28253.37 Da
• Isoelectric Point: 8.0554

>T106166 WP_033969419.1 NZ_CP029660:c3208179-3207424 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQATPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVNGKLPHPA

Nucleotide

• Length: 756 bp

>T106166 NZ_CP029660:c3208179-3207424 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGGCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAGCAGGCATTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGACGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTCGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGCAGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGCCTGCAGGCAACGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGGAGCGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTACCGGGATCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGAACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT106166 WP_003086329.1 NZ_CP029660:c3208682-3208314 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT106166 NZ_CP029660:c3208682-3208314 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTCGCCGCGCGCGAGCAATTGGG
ACTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGGGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
TCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Structures

Toxin

• AlphaFold DB: A0A6A9JV85

Antitoxin

• AlphaFold DB: V6AJU7