106165

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2248709..2249929 Replicon chromosome
Accession NZ_CP029660
Organism Pseudomonas aeruginosa strain AR_0446

Toxin (Protein)


Gene name vapC Uniprot ID A0A6A9JMS7
Locus tag CSC33_RS10470 Protein ID WP_033978781.1
Coordinates 2249351..2249929 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6A9JWC3
Locus tag CSC33_RS10465 Protein ID WP_033978782.1
Coordinates 2248709..2249263 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC33_RS10440 2244280..2244831 + 552 WP_033978785.1 XRE family transcriptional regulator -
CSC33_RS10445 2244828..2245226 - 399 WP_023436383.1 NADH-quinone oxidoreductase subunit A -
CSC33_RS10450 2245239..2245562 - 324 WP_003102734.1 multidrug efflux SMR transporter -
CSC33_RS10455 2245893..2246354 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
CSC33_RS10460 2246359..2248554 + 2196 WP_110194039.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
CSC33_RS10465 2248709..2249263 + 555 WP_033978782.1 helix-turn-helix domain-containing protein Antitoxin
CSC33_RS10470 2249351..2249929 + 579 WP_033978781.1 HD domain-containing protein Toxin
CSC33_RS10475 2250038..2251225 - 1188 WP_051488647.1 HlyD family efflux transporter periplasmic adaptor subunit -
CSC33_RS10480 2251215..2253386 - 2172 WP_058179113.1 type I secretion system permease/ATPase -
CSC33_RS10485 2253376..2254653 - 1278 WP_003160086.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-172)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21839.67 Da        Isoelectric Point: 5.3655

>T106165 WP_033978781.1 NZ_CP029660:2249351-2249929 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKALRELLDARTRQRLAARRDA

Download         Length: 579 bp

>T106165 NZ_CP029660:2249351-2249929 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGTCGCCCGGAAAGCACCGCCGAACACAGTTGGCGGCTGTGCCTGATGGCTCTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCTTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCATCTGGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGGCCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20514.68 Da        Isoelectric Point: 8.1590

>AT106165 WP_033978782.1 NZ_CP029660:2248709-2249263 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPTRAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANTSAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT106165 NZ_CP029660:2248709-2249263 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTTCCCTCTTCGTCCCTGGGCCCCGCCCTGCGCCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCACGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCTTGCTGGCCTGTTCGCCGACACGCGCCGCGCAATTCGGCGT
GCCCCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACACCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTACGCCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A9JMS7

Antitoxin

Source ID Structure
AlphaFold DB A0A6A9JWC3

References