Detailed information of TA system TA106164

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 1333081..1333876
• Replicon: chromosome
• Accession: NZ_CP029660
• Organism: Pseudomonas aeruginosa strain AR_0446

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CSC33_RS06465
• Protein ID: WP_110193808.1
• Coordinates: 1333697..1333876 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CSC33_RS06460
• Protein ID: WP_110193807.1
• Coordinates: 1333081..1333656 (-)
• Length: 192 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC33_RS06420	1328276..1328944	-	669	WP_033978087.1	Bax inhibitor-1/YccA family protein	-
CSC33_RS06430	1329280..1330002	-	723	Protein_1238	tyrosine-type recombinase/integrase	-
CSC33_RS31265	1330467..1331487	-	1021	Protein_1239	site-specific DNA-methyltransferase	-
CSC33_RS31055	1331816..1332169	-	354	WP_139262379.1	hypothetical protein	-
CSC33_RS06450	1332360..1332611	-	252	Protein_1241	S24 family peptidase	-
CSC33_RS06455	1332613..1333068	+	456	Protein_1242	transposase	-
CSC33_RS06460	1333081..1333656	-	576	WP_110193807.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CSC33_RS06465	1333697..1333876	-	180	WP_110193808.1	type II toxin-antitoxin system HicA family toxin	Toxin
CSC33_RS06470	1334038..1335686	+	1649	Protein_1245	phage tail tape measure protein	-
CSC33_RS06475	1335692..1336030	+	339	WP_110193809.1	phage tail protein	-
CSC33_RS06480	1336027..1336772	+	746	Protein_1247	phage minor tail protein L	-
CSC33_RS06485	1336775..1337530	+	756	WP_110193810.1	C40 family peptidase	-
CSC33_RS06490	1337556..1337804	+	249	WP_110193811.1	hypothetical protein	-
CSC33_RS06495	1337827..1338864	-	1038	WP_023088306.1	P63C domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1328276..1355688	27412

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (11-78)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6651.72 Da
• Isoelectric Point: 11.1475

>T106164 WP_110193808.1 NZ_CP029660:c1333876-1333697 [Pseudomonas aeruginosa]
MKFSEFRRWLRAQGVTFEAGKGSHFKVTALNGKTTTFADHGTKEMPEPTRKAIIKQLGL

Nucleotide

• Length: 180 bp

>T106164 NZ_CP029660:c1333876-1333697 [Pseudomonas aeruginosa]
ATGAAGTTCAGCGAATTCCGACGCTGGCTAAGGGCGCAAGGCGTGACCTTCGAAGCTGGCAAGGGCAGTCACTTCAAGGT
GACCGCCCTGAACGGTAAGACAACAACCTTCGCAGATCACGGCACCAAAGAAATGCCGGAGCCGACACGCAAGGCGATCA
TCAAGCAACTGGGGCTCTGA

Antitoxin

Protein

• Length: 192 a.a.
• Molecular weight: 21260.76 Da
• Isoelectric Point: 8.3556

>AT106164 WP_110193807.1 NZ_CP029660:c1333656-1333081 [Pseudomonas aeruginosa]
MYNFAIRFEQDDSAPGVAVFCRDLPELNSYGDTVEHALSEAVDAIETTLSLYVDQRRSIPAASAPEPEEHVVHLPAVTVA
KIALWNEMMRRGMRKADLCRVLGIAQVQGDRLVDFLHTSKMEQVESALAALEMRLVICAEPVKQPKQCKGAGCIRDRRLV
KARRLLRARLLELTESSGVLTRAPKIKKPGI

Nucleotide

• Length: 576 bp

>AT106164 NZ_CP029660:c1333656-1333081 [Pseudomonas aeruginosa]
ATGTACAACTTCGCAATCCGTTTCGAGCAGGACGACAGCGCTCCTGGCGTTGCCGTTTTCTGTCGAGACCTTCCAGAGCT
GAACAGCTACGGAGACACCGTCGAGCACGCGCTCAGCGAGGCCGTTGATGCCATCGAAACCACATTGTCGCTCTACGTTG
ATCAACGCCGATCAATTCCAGCGGCTAGCGCTCCAGAGCCAGAAGAGCATGTCGTACATCTTCCGGCTGTGACCGTCGCA
AAGATCGCTCTATGGAATGAGATGATGAGGCGAGGCATGAGGAAGGCAGATCTATGCCGGGTGCTTGGCATCGCCCAAGT
GCAGGGAGATCGTCTTGTCGACTTCTTGCATACATCGAAAATGGAGCAGGTCGAAAGCGCACTGGCCGCACTTGAAATGC
GCCTTGTGATTTGCGCCGAGCCAGTCAAGCAACCGAAGCAGTGCAAGGGCGCAGGCTGTATTCGAGATCGGCGACTCGTT
AAAGCACGCCGCCTGCTGCGCGCCCGGCTCCTTGAACTAACCGAATCTAGCGGCGTGTTGACGCGCGCTCCCAAAATCAA
AAAGCCCGGCATCTGA