Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 10582..11252 Replicon chromosome
Accession NZ_CP029660
Organism Pseudomonas aeruginosa strain AR_0446

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CSC33_RS00050 Protein ID WP_033981739.1
Coordinates 10833..11252 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CSC33_RS00045 Protein ID WP_033981738.1
Coordinates 10582..10836 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC33_RS00025 6114..7106 - 993 WP_201011868.1 LuxR family transcriptional regulator -
CSC33_RS00030 7200..7424 + 225 WP_023114650.1 AlpA family phage regulatory protein -
CSC33_RS00035 7427..8320 + 894 WP_033981612.1 helicase RepA family protein -
CSC33_RS00040 8301..9278 + 978 WP_033981617.1 plasmid replication -
CSC33_RS00045 10582..10836 + 255 WP_033981738.1 Arc family DNA-binding protein Antitoxin
CSC33_RS00050 10833..11252 + 420 WP_033981739.1 type II toxin-antitoxin system VapC family toxin Toxin
CSC33_RS00055 11409..12179 + 771 WP_033981842.1 P-type conjugative transfer protein TrbJ -
CSC33_RS31025 12190..12348 + 159 WP_153562500.1 hypothetical protein -
CSC33_RS00060 12350..13804 + 1455 WP_033981741.1 P-type conjugative transfer protein TrbL -
CSC33_RS00065 13873..14115 + 243 WP_033981742.1 type I toxin-antitoxin system ptaRNA1 family toxin -
CSC33_RS00070 14127..14411 + 285 WP_033981744.1 hypothetical protein -
CSC33_RS00075 14414..14782 + 369 WP_033981746.1 conjugal transfer transcriptional regulator TraJ -
CSC33_RS00080 14821..15279 - 459 WP_071536287.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14910.10 Da        Isoelectric Point: 4.9108

>T106162 WP_033981739.1 NZ_CP029660:10833-11252 [Pseudomonas aeruginosa]
MIVLDTNVVSEAMKPEPNPAVRAWLNEQVAETLYLSSVTLAELLFGIGALPNGKRKKGLGEALDGLLELFGERVLMFDTE
AARHYAELAVKARTAGKGFPTPDGYIGAIAAARGFIVATRDTSPFEAAGLTVINPWDHQ

Download         Length: 420 bp

>T106162 NZ_CP029660:10833-11252 [Pseudomonas aeruginosa]
ATGATCGTCTTGGATACGAATGTCGTCTCCGAGGCGATGAAACCCGAACCCAACCCGGCTGTGCGAGCTTGGTTGAATGA
GCAGGTAGCGGAAACACTTTACCTGTCCAGCGTGACGCTGGCCGAGTTGCTGTTTGGCATCGGCGCGTTGCCGAACGGGA
AGCGTAAGAAAGGCCTGGGCGAAGCCCTGGACGGCTTGCTCGAGCTCTTCGGAGAGCGGGTGTTGATGTTCGACACCGAA
GCAGCTCGTCATTATGCCGAGCTGGCGGTGAAGGCCCGCACAGCCGGGAAGGGTTTCCCAACACCCGACGGATATATTGG
GGCTATCGCGGCCGCCAGAGGATTTATCGTAGCAACACGCGATACCAGCCCTTTTGAAGCGGCTGGGCTTACTGTTATCA
ATCCTTGGGACCATCAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9494.84 Da        Isoelectric Point: 6.4760

>AT106162 WP_033981738.1 NZ_CP029660:10582-10836 [Pseudomonas aeruginosa]
MAILTVRNVPDEVHRALRLRAAEHGRSTEAEVREILESAVKSEKRVRMGDALAELGRRVGLTNDDFAVLDQVRDKVPAEP
MRFE

Download         Length: 255 bp

>AT106162 NZ_CP029660:10582-10836 [Pseudomonas aeruginosa]
ATGGCAATCCTGACAGTGCGAAATGTGCCTGACGAGGTGCATCGCGCTCTGCGCTTACGGGCCGCCGAGCATGGCCGCAG
CACAGAGGCGGAGGTGCGCGAGATTCTGGAAAGTGCGGTGAAGTCGGAAAAGCGTGTCCGTATGGGCGATGCTCTGGCGG
AGCTTGGCCGTCGCGTTGGGCTGACAAACGATGATTTCGCTGTGTTGGACCAGGTGCGAGACAAAGTGCCGGCAGAACCG
ATGAGGTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References