Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2188931..2189408 Replicon chromosome
Accession NZ_CP029658
Organism Staphylococcus aureus strain AR_0467

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CSC52_RS11775 Protein ID WP_000052076.1
Coordinates 2189220..2189408 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CSC52_RS11770 Protein ID WP_001059690.1
Coordinates 2188931..2189191 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC52_RS11735 2184324..2185040 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
CSC52_RS11740 2185188..2185610 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
CSC52_RS11745 2186009..2186503 + 495 WP_000569883.1 GNAT family N-acetyltransferase -
CSC52_RS11750 2186658..2187275 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
CSC52_RS11755 2187348..2187929 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
CSC52_RS11760 2188154..2188390 + 237 WP_000349581.1 hypothetical protein -
CSC52_RS11765 2188387..2188590 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CSC52_RS11770 2188931..2189191 + 261 WP_001059690.1 hypothetical protein Antitoxin
CSC52_RS11775 2189220..2189408 + 189 WP_000052076.1 hypothetical protein Toxin
CSC52_RS11780 2189596..2190165 + 570 WP_001106658.1 hypothetical protein -
CSC52_RS11785 2190253..2190537 + 285 WP_001004399.1 hypothetical protein -
CSC52_RS11790 2190599..2190817 + 219 WP_000005886.1 hypothetical protein -
CSC52_RS11795 2191309..2191509 - 201 WP_001059082.1 cold-shock protein -
CSC52_RS11800 2191866..2192552 - 687 WP_000141557.1 thermonuclease family protein -
CSC52_RS11805 2192893..2193414 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T106161 WP_000052076.1 NZ_CP029658:2189220-2189408 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T106161 NZ_CP029658:2189220-2189408 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT106161 WP_001059690.1 NZ_CP029658:2188931-2189191 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT106161 NZ_CP029658:2188931-2189191 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References