Detailed information of TA system TA106155

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1056450..1057226
• Replicon: chromosome
• Accession: NZ_CP029658
• Organism: Staphylococcus aureus strain AR_0467

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: CSC52_RS05815
• Protein ID: WP_110184175.1
• Coordinates: 1057074..1057226 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: CSC52_RS05810
• Protein ID: WP_001251224.1
• Coordinates: 1056450..1057049 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC52_RS05790	1052366..1053823	+	1458	WP_000649908.1	ABC transporter permease subunit	-
CSC52_RS05795	1053816..1054538	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
CSC52_RS05800	1054689..1055816	+	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
CSC52_RS05805	1055821..1056291	+	471	WP_000181395.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
CSC52_RS05810	1056450..1057049	+	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
CSC52_RS05815	1057074..1057226	+	153	WP_110184175.1	hypothetical protein	Toxin
CSC52_RS05820	1057774..1058169	+	396	WP_000901023.1	hypothetical protein	-
CSC52_RS05825	1058365..1059750	+	1386	WP_000116228.1	class II fumarate hydratase	-
CSC52_RS05830	1060203..1061024	-	822	WP_000669376.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5970.30 Da
• Isoelectric Point: 3.8962

>T106155 WP_110184175.1 NZ_CP029658:1057074-1057226 [Staphylococcus aureus]
MSKDKDPKFNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T106155 NZ_CP029658:1057074-1057226 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTTAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT106155 WP_001251224.1 NZ_CP029658:1056450-1057049 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT106155 NZ_CP029658:1056450-1057049 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: W8U4V4