Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 859902..860379 Replicon chromosome
Accession NZ_CP029657
Organism Staphylococcus aureus strain AR_0468

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CSC53_RS04410 Protein ID WP_000052076.1
Coordinates 859902..860090 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CSC53_RS04415 Protein ID WP_001059690.1
Coordinates 860119..860379 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC53_RS04380 855896..856417 + 522 WP_000824482.1 hypothetical protein -
CSC53_RS04385 856758..857444 + 687 WP_000141557.1 thermonuclease family protein -
CSC53_RS04390 857801..858001 + 201 WP_001059082.1 cold-shock protein -
CSC53_RS04395 858493..858711 - 219 WP_000005886.1 hypothetical protein -
CSC53_RS04400 858773..859057 - 285 WP_001004399.1 hypothetical protein -
CSC53_RS04405 859145..859714 - 570 WP_001106658.1 hypothetical protein -
CSC53_RS04410 859902..860090 - 189 WP_000052076.1 hypothetical protein Toxin
CSC53_RS04415 860119..860379 - 261 WP_001059690.1 hypothetical protein Antitoxin
CSC53_RS04420 860720..860923 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CSC53_RS04425 860920..861156 - 237 WP_000349581.1 hypothetical protein -
CSC53_RS04430 861381..861962 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
CSC53_RS04435 862035..862652 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
CSC53_RS04440 862807..863301 - 495 WP_000569883.1 GNAT family N-acetyltransferase -
CSC53_RS04445 863700..864122 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
CSC53_RS04450 864270..864986 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T106124 WP_000052076.1 NZ_CP029657:c860090-859902 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T106124 NZ_CP029657:c860090-859902 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT106124 WP_001059690.1 NZ_CP029657:c860379-860119 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT106124 NZ_CP029657:c860379-860119 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References