Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2562243..2562720 Replicon chromosome
Accession NZ_CP029655
Organism Staphylococcus aureus strain AR_0469

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CSC54_RS13525 Protein ID WP_000052076.1
Coordinates 2562532..2562720 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CSC54_RS13520 Protein ID WP_001059690.1
Coordinates 2562243..2562503 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC54_RS13485 2557636..2558352 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
CSC54_RS13490 2558500..2558922 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
CSC54_RS13495 2559321..2559815 + 495 WP_000569883.1 GNAT family N-acetyltransferase -
CSC54_RS13500 2559970..2560587 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
CSC54_RS13505 2560660..2561241 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
CSC54_RS13510 2561466..2561702 + 237 WP_000349581.1 hypothetical protein -
CSC54_RS13515 2561699..2561902 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CSC54_RS13520 2562243..2562503 + 261 WP_001059690.1 hypothetical protein Antitoxin
CSC54_RS13525 2562532..2562720 + 189 WP_000052076.1 hypothetical protein Toxin
CSC54_RS13530 2562908..2563477 + 570 WP_001106658.1 hypothetical protein -
CSC54_RS13535 2563565..2563834 + 270 WP_001004398.1 hypothetical protein -
CSC54_RS13540 2563911..2564129 + 219 WP_000005886.1 hypothetical protein -
CSC54_RS13545 2564621..2564821 - 201 WP_001059082.1 cold-shock protein -
CSC54_RS13550 2565178..2565864 - 687 WP_000141557.1 thermonuclease family protein -
CSC54_RS13555 2566205..2566726 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T106123 WP_000052076.1 NZ_CP029655:2562532-2562720 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T106123 NZ_CP029655:2562532-2562720 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT106123 WP_001059690.1 NZ_CP029655:2562243-2562503 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT106123 NZ_CP029655:2562243-2562503 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References