Detailed information of TA system TA106119

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1280315..1280844
• Replicon: chromosome
• Accession: NZ_CP029655
• Organism: Staphylococcus aureus strain AR_0469

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: CSC54_RS06680
• Protein ID: WP_000621175.1
• Coordinates: 1280482..1280844 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: CSC54_RS06675
• Protein ID: WP_000948331.1
• Coordinates: 1280315..1280485 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC54_RS06645	1275352..1275912	+	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-
CSC54_RS06650	1276120..1276599	+	480	WP_001287087.1	hypothetical protein	-
CSC54_RS06655	1276592..1278175	+	1584	WP_001294626.1	PH domain-containing protein	-
CSC54_RS06660	1278162..1278653	+	492	WP_001205912.1	PH domain-containing protein	-
CSC54_RS06665	1278657..1279016	+	360	WP_000581197.1	holo-ACP synthase	-
CSC54_RS06670	1279082..1280230	+	1149	WP_001281154.1	alanine racemase	-
CSC54_RS06675	1280315..1280485	+	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
CSC54_RS06680	1280482..1280844	+	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
CSC54_RS06690	1281194..1282195	+	1002	WP_031786866.1	PP2C family protein-serine/threonine phosphatase	-
CSC54_RS06695	1282314..1282640	+	327	WP_001052491.1	anti-sigma factor antagonist	-
CSC54_RS06700	1282642..1283121	+	480	WP_001190829.1	anti-sigma B factor RsbW	-
CSC54_RS06705	1283096..1283866	+	771	WP_001041111.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T106119 WP_000621175.1 NZ_CP029655:1280482-1280844 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T106119 NZ_CP029655:1280482-1280844 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT106119 WP_000948331.1 NZ_CP029655:1280315-1280485 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT106119 NZ_CP029655:1280315-1280485 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1