Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2282776..2283305 Replicon chromosome
Accession NZ_CP029653
Organism Staphylococcus aureus strain AR_0470

Toxin (Protein)


Gene name mazF Uniprot ID Q6GF05
Locus tag CSC55_RS11720 Protein ID WP_000621176.1
Coordinates 2282776..2283138 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag CSC55_RS11725 Protein ID WP_000948331.1
Coordinates 2283135..2283305 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC55_RS11695 2279755..2280525 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
CSC55_RS11700 2280500..2280979 - 480 WP_001190825.1 anti-sigma B factor RsbW -
CSC55_RS11705 2280981..2281307 - 327 WP_001052491.1 anti-sigma factor antagonist -
CSC55_RS11710 2281426..2282427 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
CSC55_RS11720 2282776..2283138 - 363 WP_000621176.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CSC55_RS11725 2283135..2283305 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
CSC55_RS11730 2283390..2284538 - 1149 WP_001573493.1 alanine racemase -
CSC55_RS11735 2284604..2284963 - 360 WP_000581197.1 holo-ACP synthase -
CSC55_RS11740 2284967..2285458 - 492 WP_001286801.1 PH domain-containing protein -
CSC55_RS11745 2285451..2287028 - 1578 WP_001294646.1 PH domain-containing protein -
CSC55_RS11750 2287021..2287500 - 480 WP_001287082.1 hypothetical protein -
CSC55_RS11755 2287709..2288269 - 561 WP_001092414.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13469.74 Da        Isoelectric Point: 10.1654

>T106100 WP_000621176.1 NZ_CP029653:c2283138-2282776 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVVHQKN

Download         Length: 363 bp

>T106100 NZ_CP029653:c2283138-2282776 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACATACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGTTCATCAGAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT106100 WP_000948331.1 NZ_CP029653:c2283305-2283135 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT106100 NZ_CP029653:c2283305-2283135 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A168PYX0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References