106092

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 915270..915747 Replicon chromosome
Accession NZ_CP029653
Organism Staphylococcus aureus strain AR_0470

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CSC55_RS04480 Protein ID WP_000052076.1
Coordinates 915270..915458 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CSC55_RS04485 Protein ID WP_001059690.1
Coordinates 915487..915747 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC55_RS04450 911223..911780 + 558 WP_000824491.1 hypothetical protein -
CSC55_RS04455 912121..912807 + 687 WP_001574556.1 thermonuclease family protein -
CSC55_RS04460 913164..913364 + 201 WP_001059082.1 cold-shock protein -
CSC55_RS04465 913861..914079 - 219 WP_000005879.1 hypothetical protein -
CSC55_RS04470 914141..914425 - 285 WP_001004401.1 hypothetical protein -
CSC55_RS04475 914513..915082 - 570 WP_001106663.1 hypothetical protein -
CSC55_RS04480 915270..915458 - 189 WP_000052076.1 hypothetical protein Toxin
CSC55_RS04485 915487..915747 - 261 WP_001059690.1 hypothetical protein Antitoxin
CSC55_RS04490 916088..916291 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CSC55_RS04495 916288..916524 - 237 WP_000368687.1 hypothetical protein -
CSC55_RS04500 916749..917330 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
CSC55_RS04505 917403..918020 - 618 WP_000255548.1 LysE/ArgO family amino acid transporter -
CSC55_RS04510 918176..918670 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
CSC55_RS04515 919069..919491 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
CSC55_RS04520 919639..920355 + 717 WP_000150022.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sec / sell / vWbp 877285..917330 40045


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T106092 WP_000052076.1 NZ_CP029653:c915458-915270 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T106092 NZ_CP029653:c915458-915270 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT106092 WP_001059690.1 NZ_CP029653:c915747-915487 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT106092 NZ_CP029653:c915747-915487 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References