Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2346469..2346983 Replicon chromosome
Accession NZ_CP029652
Organism Staphylococcus aureus strain AR_0471

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag CSC56_RS12150 Protein ID WP_000581795.1
Coordinates 2346774..2346983 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0U1MQV0
Locus tag CSC56_RS12145 Protein ID WP_000138930.1
Coordinates 2346469..2346762 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC56_RS12120 2341995..2342636 + 642 WP_000483162.1 thiamine phosphate synthase -
CSC56_RS12125 2342722..2343594 + 873 WP_000725802.1 membrane protein insertase YidC -
CSC56_RS12135 2344144..2344791 - 648 WP_001187625.1 HD domain-containing protein -
CSC56_RS12140 2344819..2346303 - 1485 WP_000571562.1 cardiolipin synthase -
CSC56_RS12145 2346469..2346762 + 294 WP_000138930.1 copper-sensing transcriptional repressor CsoR Antitoxin
CSC56_RS12150 2346774..2346983 + 210 WP_000581795.1 heavy-metal-associated domain-containing protein Toxin
CSC56_RS12155 2347111..2347248 + 138 WP_000828354.1 hypothetical protein -
CSC56_RS12160 2347512..2348714 - 1203 WP_001109939.1 rod shape-determining protein RodA -
CSC56_RS12165 2349032..2350102 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
CSC56_RS12170 2350117..2351475 + 1359 WP_000611479.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T106085 WP_000581795.1 NZ_CP029652:2346774-2346983 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T106085 NZ_CP029652:2346774-2346983 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAAAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11169.81 Da        Isoelectric Point: 6.2242

>AT106085 WP_000138930.1 NZ_CP029652:2346469-2346762 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVKAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT106085 NZ_CP029652:2346469-2346762 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAAAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CATTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1MQV0

References