Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 836176..836653 Replicon chromosome
Accession NZ_CP029652
Organism Staphylococcus aureus strain AR_0471

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CSC56_RS04555 Protein ID WP_000052076.1
Coordinates 836465..836653 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CSC56_RS04550 Protein ID WP_001059690.1
Coordinates 836176..836436 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC56_RS04515 831569..832285 - 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -
CSC56_RS04520 832433..832855 + 423 WP_000974451.1 organic hydroperoxide resistance protein -
CSC56_RS04525 833254..833748 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
CSC56_RS04530 833904..834521 + 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
CSC56_RS04535 834594..835175 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
CSC56_RS04540 835399..835635 + 237 WP_000368687.1 hypothetical protein -
CSC56_RS04545 835632..835835 - 204 WP_000145160.1 sterile alpha motif-like domain-containing protein -
CSC56_RS04550 836176..836436 + 261 WP_001059690.1 hypothetical protein Antitoxin
CSC56_RS04555 836465..836653 + 189 WP_000052076.1 hypothetical protein Toxin
CSC56_RS04560 836841..837410 + 570 WP_001106662.1 hypothetical protein -
CSC56_RS04565 837498..837770 + 273 WP_001004400.1 hypothetical protein -
CSC56_RS04570 837843..838061 + 219 WP_000005884.1 hypothetical protein -
CSC56_RS04575 838558..838758 - 201 WP_001059082.1 cold-shock protein -
CSC56_RS04580 839115..839801 - 687 WP_001622483.1 thermonuclease family protein -
CSC56_RS04585 840142..840663 - 522 WP_000824479.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp / sell / sec / tsst-1 774287..870178 95891


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T106082 WP_000052076.1 NZ_CP029652:836465-836653 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T106082 NZ_CP029652:836465-836653 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT106082 WP_001059690.1 NZ_CP029652:836176-836436 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT106082 NZ_CP029652:836176-836436 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References