Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 813639..814427 | Replicon | chromosome |
| Accession | NZ_CP029652 | ||
| Organism | Staphylococcus aureus strain AR_0471 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A2I7Y5B3 |
| Locus tag | CSC56_RS04395 | Protein ID | WP_000525004.1 |
| Coordinates | 813966..814427 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0E7YIA0 |
| Locus tag | CSC56_RS04390 | Protein ID | WP_000333630.1 |
| Coordinates | 813639..813953 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CSC56_RS04335 | 809239..809460 | - | 222 | WP_000815403.1 | DUF2483 family protein | - |
| CSC56_RS04340 | 809470..809730 | - | 261 | WP_000291068.1 | DUF1108 family protein | - |
| CSC56_RS04345 | 809822..809983 | - | 162 | WP_000066011.1 | DUF1270 domain-containing protein | - |
| CSC56_RS04350 | 809976..810197 | - | 222 | WP_000594789.1 | hypothetical protein | - |
| CSC56_RS04355 | 810268..810921 | + | 654 | WP_015978329.1 | hypothetical protein | - |
| CSC56_RS04360 | 810931..811074 | - | 144 | WP_015978350.1 | hypothetical protein | - |
| CSC56_RS04365 | 811090..811842 | - | 753 | WP_070992099.1 | phage antirepressor KilAC domain-containing protein | - |
| CSC56_RS04370 | 811844..812029 | - | 186 | WP_000933365.1 | helix-turn-helix transcriptional regulator | - |
| CSC56_RS04375 | 812475..812957 | + | 483 | WP_070992098.1 | hypothetical protein | - |
| CSC56_RS04380 | 813058..813237 | - | 180 | WP_000438352.1 | hypothetical protein | - |
| CSC56_RS04385 | 813251..813487 | - | 237 | WP_001121116.1 | helix-turn-helix domain-containing protein | - |
| CSC56_RS04390 | 813639..813953 | + | 315 | WP_000333630.1 | helix-turn-helix domain-containing protein | Antitoxin |
| CSC56_RS04395 | 813966..814427 | + | 462 | WP_000525004.1 | hypothetical protein | Toxin |
| CSC56_RS04400 | 814611..815048 | + | 438 | WP_015977901.1 | DUF4231 domain-containing protein | - |
| CSC56_RS04405 | 815042..815449 | + | 408 | WP_015977903.1 | TIR domain-containing protein | - |
| CSC56_RS04410 | 815446..815643 | - | 198 | WP_000074681.1 | hypothetical protein | - |
| CSC56_RS04415 | 815756..816805 | + | 1050 | WP_001145728.1 | site-specific integrase | - |
| CSC56_RS04420 | 816873..818270 | - | 1398 | WP_001074405.1 | Fe-S cluster assembly protein SufB | - |
| CSC56_RS04425 | 818421..818885 | - | 465 | WP_001010508.1 | SUF system NifU family Fe-S cluster assembly protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | vWbp / sell / sec / tsst-1 | 774287..870178 | 95891 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18074.46 Da Isoelectric Point: 4.6915
>T106081 WP_000525004.1 NZ_CP029652:813966-814427 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T106081 NZ_CP029652:813966-814427 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTGATAAAGCGTGGTTTATCAGATAGAGAAAAGGCAGGGATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCTGTTCCATTACGCGAAATTGTAGAAGCTTATAATTATGGCGTACGTAACTTGTATGAATT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAATACTCAATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTGATAAAGCGTGGTTTATCAGATAGAGAAAAGGCAGGGATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCTGTTCCATTACGCGAAATTGTAGAAGCTTATAATTATGGCGTACGTAACTTGTATGAATT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAATACTCAATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12063.56 Da Isoelectric Point: 6.4736
>AT106081 WP_000333630.1 NZ_CP029652:813639-813953 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
Download Length: 315 bp
>AT106081 NZ_CP029652:813639-813953 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATCAAAAATCTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCGTATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCATCTT
GAAGGAGAATTGACAGATGACGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATCAAAAATCTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCGTATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCATCTT
GAAGGAGAATTGACAGATGACGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2I7Y5B3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E7YIA0 |