Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 1372771..1373300 Replicon chromosome
Accession NZ_CP029649
Organism Staphylococcus aureus strain AR_0472

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag CSC57_RS07005 Protein ID WP_001103933.1
Coordinates 1372771..1373088 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A2X2M557
Locus tag CSC57_RS07010 Protein ID WP_001058488.1
Coordinates 1373091..1373300 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC57_RS06980 1367886..1368227 - 342 WP_001190614.1 hypothetical protein -
CSC57_RS06985 1368763..1369404 - 642 WP_064140196.1 pathogenicity island protein -
CSC57_RS06990 1369401..1369781 - 381 WP_000356927.1 hypothetical protein -
CSC57_RS06995 1370112..1371821 - 1710 WP_000447454.1 DUF927 domain-containing protein -
CSC57_RS07000 1371835..1372704 - 870 WP_001002701.1 primase alpha helix C-terminal domain-containing protein -
CSC57_RS07005 1372771..1373088 - 318 WP_001103933.1 DUF1474 family protein Toxin
CSC57_RS07010 1373091..1373300 - 210 WP_001058488.1 hypothetical protein Antitoxin
CSC57_RS14835 1373293..1373439 - 147 WP_181819064.1 hypothetical protein -
CSC57_RS07015 1373486..1373746 - 261 WP_001147662.1 hypothetical protein -
CSC57_RS07020 1373748..1373945 - 198 WP_000466891.1 helix-turn-helix transcriptional regulator -
CSC57_RS07025 1374089..1374712 + 624 WP_000431539.1 helix-turn-helix domain-containing protein -
CSC57_RS07030 1374808..1375944 + 1137 WP_000592973.1 site-specific integrase -
CSC57_RS07035 1376038..1377579 - 1542 WP_000424963.1 glutamine-hydrolyzing GMP synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sell / sec 1352186..1380376 28190


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T106064 WP_001103933.1 NZ_CP029649:c1373088-1372771 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T106064 NZ_CP029649:c1373088-1372771 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTGATGTGTGATATTGAAGTGATAAAAGAAAAAATCAATGATGTAGCTATCAAACATGG
TTGGTTTGTTGAAGATAAATTTGTCAAAAATGAATTAGAAACAAAACAGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8287.31 Da        Isoelectric Point: 4.2820

>AT106064 WP_001058488.1 NZ_CP029649:c1373300-1373091 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT106064 NZ_CP029649:c1373300-1373091 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTATCATGAATAATTTTGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAAAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2M557

References