Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 926772..927249 Replicon chromosome
Accession NZ_CP029649
Organism Staphylococcus aureus strain AR_0472

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CSC57_RS04710 Protein ID WP_000052076.1
Coordinates 927061..927249 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CSC57_RS04705 Protein ID WP_001059690.1
Coordinates 926772..927032 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC57_RS04670 922164..922880 - 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -
CSC57_RS04675 923028..923450 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
CSC57_RS04680 923849..924343 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
CSC57_RS04685 924499..925116 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
CSC57_RS04690 925189..925770 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
CSC57_RS04695 925995..926231 + 237 WP_000368687.1 hypothetical protein -
CSC57_RS04700 926228..926431 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CSC57_RS04705 926772..927032 + 261 WP_001059690.1 hypothetical protein Antitoxin
CSC57_RS04710 927061..927249 + 189 WP_000052076.1 hypothetical protein Toxin
CSC57_RS04715 927437..928006 + 570 WP_001106654.1 hypothetical protein -
CSC57_RS04720 928094..928378 + 285 WP_001004395.1 hypothetical protein -
CSC57_RS04725 928440..928658 + 219 WP_000005886.1 hypothetical protein -
CSC57_RS04730 929154..929354 - 201 WP_001059082.1 cold-shock protein -
CSC57_RS04735 929711..930397 - 687 WP_001792695.1 thermonuclease family protein -
CSC57_RS04740 930738..931259 - 522 WP_000824484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T106063 WP_000052076.1 NZ_CP029649:927061-927249 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T106063 NZ_CP029649:927061-927249 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT106063 WP_001059690.1 NZ_CP029649:926772-927032 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT106063 NZ_CP029649:926772-927032 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References