Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1950088..1950732 Replicon chromosome
Accession NZ_CP029640
Organism Paraburkholderia dokdonella strain DCT13 isolate rhisosphere

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag DMB87_RS08725 Protein ID WP_129562347.1
Coordinates 1950550..1950732 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag DMB87_RS08720 Protein ID WP_129562346.1
Coordinates 1950088..1950489 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DMB87_RS08675 1945272..1945652 + 381 WP_129562339.1 fluoride efflux transporter CrcB -
DMB87_RS08680 1945673..1946893 - 1221 WP_129562340.1 cyclopropane fatty acyl phospholipid synthase -
DMB87_RS08685 1947162..1947578 + 417 WP_129562341.1 HIT family protein -
DMB87_RS08695 1948008..1948289 - 282 WP_129562342.1 hypothetical protein -
DMB87_RS08700 1948294..1948776 - 483 WP_129562343.1 hypothetical protein -
DMB87_RS08705 1949142..1949363 - 222 WP_129562344.1 hypothetical protein -
DMB87_RS08710 1949384..1949566 - 183 WP_129562345.1 hypothetical protein -
DMB87_RS20210 1949572..1949997 - 426 WP_175196552.1 hypothetical protein -
DMB87_RS08720 1950088..1950489 - 402 WP_129562346.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DMB87_RS08725 1950550..1950732 - 183 WP_129562347.1 type II toxin-antitoxin system HicA family toxin Toxin
DMB87_RS08730 1950838..1951500 - 663 WP_129562348.1 SOS response-associated peptidase family protein -
DMB87_RS08735 1951558..1951719 + 162 Protein_1709 integrase -
DMB87_RS08740 1951761..1952732 + 972 WP_129562349.1 hypothetical protein -
DMB87_RS20010 1952942..1953316 - 375 WP_160113454.1 hypothetical protein -
DMB87_RS08745 1953842..1954165 + 324 WP_129562350.1 helix-turn-helix domain-containing protein -
DMB87_RS08750 1954178..1954657 + 480 WP_129562351.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
DMB87_RS08755 1954667..1955161 + 495 WP_129562352.1 arsenate reductase ArsC -
DMB87_RS08760 1955175..1955669 + 495 WP_129562353.1 arsenate reductase ArsC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6648.84 Da        Isoelectric Point: 11.0075

>T106056 WP_129562347.1 NZ_CP029640:c1950732-1950550 [Paraburkholderia dokdonella]
MNSSKLIRMLEEDGWQLVRVTGSHHHFKHPKKPGLVTVPHPKKDLPIGTASSILKTAGLK

Download         Length: 183 bp

>T106056 NZ_CP029640:c1950732-1950550 [Paraburkholderia dokdonella]
ATGAACTCATCAAAGCTAATCCGGATGCTCGAAGAGGATGGCTGGCAGCTGGTGCGGGTTACCGGAAGTCATCACCACTT
TAAACACCCCAAGAAGCCTGGCCTTGTGACGGTGCCGCACCCGAAGAAGGACCTGCCAATTGGGACAGCGTCGAGCATCC
TGAAAACCGCCGGTCTGAAGTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14696.59 Da        Isoelectric Point: 4.5965

>AT106056 WP_129562346.1 NZ_CP029640:c1950489-1950088 [Paraburkholderia dokdonella]
MEFPIAIHKDDGSVYGVIVPDIPGVHSWGDTIDEAIRNAREAITGHVSTLVELGEDVGFTCSTIEDLAASKEYEGAVWAL
VDVDLTKLDSKPERINISLPRFVLHKIDTYVEKRHETRSGFLARVALEALAHE

Download         Length: 402 bp

>AT106056 NZ_CP029640:c1950489-1950088 [Paraburkholderia dokdonella]
ATGGAATTTCCCATCGCGATCCATAAGGACGATGGGAGCGTCTATGGAGTTATCGTTCCGGACATTCCGGGCGTTCACTC
TTGGGGCGACACCATCGATGAAGCAATCAGGAACGCCAGAGAAGCGATCACCGGCCACGTTTCTACTTTGGTCGAGCTGG
GTGAGGATGTCGGATTCACGTGCTCAACCATTGAGGATCTGGCCGCAAGTAAAGAGTACGAAGGGGCTGTTTGGGCATTG
GTTGACGTTGATCTGACCAAGCTCGATAGCAAGCCGGAGAGGATTAACATCAGCCTTCCACGGTTCGTTTTGCACAAGAT
CGACACTTATGTCGAGAAGCGGCATGAAACAAGAAGCGGGTTTCTCGCGCGCGTAGCCTTGGAGGCATTGGCGCACGAAT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References