Detailed information of TA system TA106054

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1587907..1588512
• Replicon: chromosome
• Accession: NZ_CP029639
• Organism: Paenibacillus sp. DCT19 isolate rhisosphere

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: W4B4V0
• Locus tag: DMB88_RS06905
• Protein ID: WP_024630714.1
• Coordinates: 1588162..1588512 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: DMB88_RS06900
• Protein ID: WP_170948137.1
• Coordinates: 1587907..1588158 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DMB88_RS06890	1584628..1585827	+	1200	WP_128100757.1	DUF4367 domain-containing protein	-
DMB88_RS06895	1586426..1587613	+	1188	WP_128100758.1	alanine racemase	-
DMB88_RS06900	1587907..1588158	+	252	WP_170948137.1	ribbon-helix-helix protein, CopG family	Antitoxin
DMB88_RS06905	1588162..1588512	+	351	WP_024630714.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
DMB88_RS06910	1588829..1591018	+	2190	WP_128100759.1	alpha-galactosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-113)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-36)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12778.77 Da
• Isoelectric Point: 5.1184

>T106054 WP_024630714.1 NZ_CP029639:1588162-1588512 [Paenibacillus sp. DCT19]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTCIVAAITAQIQKAKLPTHVEIDAAAHGFDRDSVILLEQI
RTIDKQRLTDKITHLDEETMKLVNEALQISLGLIDF

Nucleotide

• Length: 351 bp

>T106054 NZ_CP029639:1588162-1588512 [Paenibacillus sp. DCT19]
TTGATCGTAAAACGCGGTGACGTTTTTTTTGCGGATCTTTCTCCCGTTGTCGGTTCCGAGCAAGGTGGAGTCAGACCGGT
GCTGGTCATCCAGAATGACATCGGTAATCGATTCAGTCCAACTTGTATTGTGGCGGCGATTACCGCCCAGATCCAAAAGG
CAAAGTTGCCGACGCATGTAGAGATTGATGCGGCGGCACATGGCTTTGACCGGGATTCGGTTATTTTGCTCGAACAAATA
CGGACGATTGACAAGCAAAGATTGACTGACAAGATTACTCATTTGGACGAGGAGACCATGAAGTTGGTTAACGAGGCCTT
ACAGATCAGTCTGGGCTTGATCGATTTTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9558.96 Da
• Isoelectric Point: 5.1255

>AT106054 WP_170948137.1 NZ_CP029639:1587907-1588158 [Paenibacillus sp. DCT19]
MISLPDHLLQEVDGIVALENSNRSELIRQAMKLYLTERKKRYIRESMQRGYMEMAKINLTMASEAFHAEEDADSTLDRLV
SGV

Nucleotide

• Length: 252 bp

>AT106054 NZ_CP029639:1587907-1588158 [Paenibacillus sp. DCT19]
ATGATCAGTCTGCCTGATCATCTTTTGCAGGAAGTGGATGGCATCGTAGCGCTGGAGAACTCCAACCGCAGCGAATTGAT
TAGGCAGGCCATGAAGCTGTATCTGACGGAACGGAAGAAGCGGTATATCCGTGAGTCTATGCAGCGTGGGTACATGGAGA
TGGCGAAGATTAACCTAACCATGGCATCCGAGGCCTTTCACGCGGAGGAAGATGCGGACAGCACTCTGGACCGCTTAGTT
AGCGGGGTGTAG

Structures

Toxin

• AlphaFold DB: W4B4V0