Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1932007..1932484 Replicon chromosome
Accession NZ_CP029629
Organism Staphylococcus aureus strain MOK063

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag DLJ56_RS10020 Protein ID WP_000052076.1
Coordinates 1932296..1932484 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag DLJ56_RS10015 Protein ID WP_001059690.1
Coordinates 1932007..1932267 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLJ56_RS09980 1927400..1928116 - 717 WP_000150013.1 type I 3-dehydroquinate dehydratase -
DLJ56_RS09985 1928264..1928686 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
DLJ56_RS09990 1929085..1929579 + 495 WP_000569887.1 GNAT family N-acetyltransferase -
DLJ56_RS09995 1929734..1930351 + 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
DLJ56_RS10000 1930424..1931005 - 582 WP_001140697.1 phosphoglycerate mutase family protein -
DLJ56_RS10005 1931230..1931466 + 237 WP_000368687.1 hypothetical protein -
DLJ56_RS10010 1931463..1931666 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
DLJ56_RS10015 1932007..1932267 + 261 WP_001059690.1 hypothetical protein Antitoxin
DLJ56_RS10020 1932296..1932484 + 189 WP_000052076.1 hypothetical protein Toxin
DLJ56_RS10025 1932672..1933241 + 570 WP_001106653.1 hypothetical protein -
DLJ56_RS10030 1933329..1933613 + 285 Protein_1839 hypothetical protein -
DLJ56_RS10035 1933675..1933893 + 219 WP_000005884.1 hypothetical protein -
DLJ56_RS10040 1934388..1934588 - 201 WP_001059082.1 cold-shock protein -
DLJ56_RS10045 1934945..1935631 - 687 WP_001548082.1 thermonuclease family protein -
DLJ56_RS10050 1935972..1936442 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T106049 WP_000052076.1 NZ_CP029629:1932296-1932484 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T106049 NZ_CP029629:1932296-1932484 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT106049 WP_001059690.1 NZ_CP029629:1932007-1932267 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT106049 NZ_CP029629:1932007-1932267 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References