Detailed information of TA system TA106046

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 648726..649240
• Replicon: chromosome
• Accession: NZ_CP029629
• Organism: Staphylococcus aureus strain MOK063

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: DLJ56_RS03335
• Protein ID: WP_000581794.1
• Coordinates: 649031..649240 (+)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: W8UW13
• Locus tag: DLJ56_RS03330
• Protein ID: WP_000138932.1
• Coordinates: 648726..649019 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DLJ56_RS03300	644197..644838	+	642	WP_000483153.1	thiamine phosphate synthase	-
DLJ56_RS03305	644924..645796	+	873	WP_000725802.1	membrane protein insertase YidC	-
DLJ56_RS03320	646401..647048	-	648	WP_001187630.1	HD domain-containing protein	-
DLJ56_RS03325	647076..648560	-	1485	WP_000571549.1	cardiolipin synthase	-
DLJ56_RS03330	648726..649019	+	294	WP_000138932.1	copper-sensing transcriptional repressor CsoR	Antitoxin
DLJ56_RS03335	649031..649240	+	210	WP_000581794.1	heavy-metal-associated domain-containing protein	Toxin
DLJ56_RS03340	649368..649505	+	138	WP_000828354.1	hypothetical protein	-
DLJ56_RS03345	649769..650971	-	1203	WP_001109939.1	rod shape-determining protein RodA	-
DLJ56_RS03350	651289..652359	+	1071	WP_000159631.1	D-alanine--D-alanine ligase	-
DLJ56_RS03355	652374..653732	+	1359	WP_000611471.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (23-66)

Antitoxin

• Metal-sensitive transcriptional repressor (14-92)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7833.73 Da
• Isoelectric Point: 4.1008

>T106046 WP_000581794.1 NZ_CP029629:649031-649240 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETSANLNSIEKEIYDEGYKIVF

Nucleotide

• Length: 210 bp

>T106046 NZ_CP029629:649031-649240 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACATCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11197.82 Da
• Isoelectric Point: 6.2243

>AT106046 WP_000138932.1 NZ_CP029629:648726-649019 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT106046 NZ_CP029629:648726-649019 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Structures

Antitoxin

• AlphaFold DB: W8UW13