Detailed information of TA system TA106040

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2178055..2178584
• Replicon: chromosome
• Accession: NZ_CP029627
• Organism: Staphylococcus aureus strain MOK042

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: DLJ55_RS11410
• Protein ID: WP_000621175.1
• Coordinates: 2178055..2178417 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: DLJ55_RS11415
• Protein ID: WP_000948331.1
• Coordinates: 2178414..2178584 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DLJ55_RS11385	2175033..2175803	-	771	WP_001041102.1	RNA polymerase sigma factor SigB	-
DLJ55_RS11390	2175778..2176257	-	480	WP_001190829.1	anti-sigma B factor RsbW	-
DLJ55_RS11395	2176259..2176585	-	327	WP_001052491.1	anti-sigma factor antagonist	-
DLJ55_RS11400	2176704..2177705	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
DLJ55_RS11410	2178055..2178417	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
DLJ55_RS11415	2178414..2178584	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
DLJ55_RS11420	2178669..2179817	-	1149	WP_001281154.1	alanine racemase	-
DLJ55_RS11425	2179883..2180242	-	360	WP_000581197.1	holo-ACP synthase	-
DLJ55_RS11430	2180246..2180737	-	492	WP_001205912.1	PH domain-containing protein	-
DLJ55_RS11435	2180724..2182307	-	1584	WP_001294622.1	PH domain-containing protein	-
DLJ55_RS11440	2182300..2182779	-	480	WP_001287079.1	hypothetical protein	-
DLJ55_RS11445	2182988..2183548	-	561	WP_001092409.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T106040 WP_000621175.1 NZ_CP029627:c2178417-2178055 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T106040 NZ_CP029627:c2178417-2178055 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT106040 WP_000948331.1 NZ_CP029627:c2178584-2178414 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT106040 NZ_CP029627:c2178584-2178414 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1