Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 878861..879338 Replicon chromosome
Accession NZ_CP029627
Organism Staphylococcus aureus strain MOK042

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag DLJ55_RS04525 Protein ID WP_000052076.1
Coordinates 878861..879049 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag DLJ55_RS04530 Protein ID WP_001059690.1
Coordinates 879078..879338 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLJ55_RS04495 874903..875373 + 471 WP_000824472.1 hypothetical protein -
DLJ55_RS04500 875714..876400 + 687 WP_001548082.1 thermonuclease family protein -
DLJ55_RS04505 876757..876957 + 201 WP_001059082.1 cold-shock protein -
DLJ55_RS04510 877452..877670 - 219 WP_000005884.1 hypothetical protein -
DLJ55_RS04515 877732..878016 - 285 WP_001004394.1 hypothetical protein -
DLJ55_RS04520 878104..878673 - 570 WP_001106653.1 hypothetical protein -
DLJ55_RS04525 878861..879049 - 189 WP_000052076.1 hypothetical protein Toxin
DLJ55_RS04530 879078..879338 - 261 WP_001059690.1 hypothetical protein Antitoxin
DLJ55_RS04535 879679..879882 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
DLJ55_RS04540 879879..880115 - 237 WP_000368687.1 hypothetical protein -
DLJ55_RS04545 880340..880921 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
DLJ55_RS04550 880994..881611 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
DLJ55_RS04555 881766..882260 - 495 WP_000569887.1 GNAT family N-acetyltransferase -
DLJ55_RS04560 882659..883081 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
DLJ55_RS04565 883229..883945 + 717 WP_000150013.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vWbp 835888..887244 51356


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T106037 WP_000052076.1 NZ_CP029627:c879049-878861 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T106037 NZ_CP029627:c879049-878861 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT106037 WP_001059690.1 NZ_CP029627:c879338-879078 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT106037 NZ_CP029627:c879338-879078 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References