106018

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 421219..421801 Replicon chromosome
Accession NZ_CP029612
Organism Enterococcus faecalis strain H25

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag CNQ40_RS02320 Protein ID WP_002355414.1
Coordinates 421493..421801 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag CNQ40_RS02315 Protein ID WP_002326825.1
Coordinates 421219..421491 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ40_RS02290 416438..416839 - 402 WP_002364925.1 sigma-70 family RNA polymerase sigma factor -
CNQ40_RS02305 420062..420916 + 855 WP_002364921.1 ParA family protein -
CNQ40_RS02310 420987..421202 + 216 WP_002355411.1 peptide-binding protein -
CNQ40_RS02315 421219..421491 + 273 WP_002326825.1 antitoxin Antitoxin
CNQ40_RS02320 421493..421801 + 309 WP_002355414.1 zeta toxin family protein Toxin
CNQ40_RS02325 421881..422309 - 429 WP_071623404.1 tyrosine-type recombinase/integrase -
CNQ40_RS02330 422354..422854 - 501 WP_002355415.1 HAD family hydrolase -
CNQ40_RS02335 422859..423626 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
CNQ40_RS02345 424114..424539 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
CNQ40_RS02350 424556..425071 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
CNQ40_RS02355 425082..426014 + 933 WP_002363040.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - bsh 406432..445636 39204


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T106018 WP_002355414.1 NZ_CP029612:421493-421801 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

>T106018 NZ_CP029612:421493-421801 [Enterococcus faecalis]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGACAACCAGGATCAGGGAAAACTAGTTTGCGATCGGCAATTT
CCGAAGAAACACAAGGAAATGTTGTTATCATTGATAATGATACGTTCAAACAACAGCACCCAAATTTTGACGAATTAGTG
AAACTCTATGAAAAAGACGTAGTAAAACATGCAACATCCTATTCTAATCAGCTGGTAAAGCTTAATTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT106018 WP_002326825.1 NZ_CP029612:421219-421491 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp

>AT106018 NZ_CP029612:421219-421491 [Enterococcus faecalis]
ATGGCAGTTACGTATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGGGTATTAAA
TTATGTTTTGAATCATGAACTAGATACTAAAAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCAC
AAGAAGTTGATTTATTTCAACAACCATTTGAAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCA
AAACAAATTTTGACAAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References