106012

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 2935039..2936759 Replicon chromosome
Accession NZ_CP029610
Organism Acinetobacter pittii strain ST220

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag DLK06_RS14395 Protein ID WP_087537449.1
Coordinates 2936100..2936759 (-) Length 220 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag DLK06_RS14390 Protein ID WP_087537450.1
Coordinates 2935039..2936103 (-) Length 355 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLK06_RS14380 2930375..2931646 + 1272 WP_087537453.1 site-specific integrase -
DLK06_RS14385 2931739..2934861 - 3123 WP_087537451.1 SIR2 family protein -
DLK06_RS14390 2935039..2936103 - 1065 WP_087537450.1 macro domain-containing protein Antitoxin
DLK06_RS14395 2936100..2936759 - 660 WP_087537449.1 DUF4433 domain-containing protein Toxin
DLK06_RS21550 2936894..2937538 - 645 WP_201798794.1 hypothetical protein -
DLK06_RS14405 2938298..2938555 + 258 WP_087537452.1 hypothetical protein -
DLK06_RS14410 2938691..2938915 + 225 WP_087537448.1 hypothetical protein -
DLK06_RS14415 2938945..2939448 + 504 WP_087537447.1 hypothetical protein -
DLK06_RS14420 2939683..2939895 + 213 WP_087537446.1 hypothetical protein -
DLK06_RS14425 2940013..2940402 + 390 WP_087537445.1 hypothetical protein -
DLK06_RS14430 2940405..2940932 + 528 WP_126117660.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2940859..2941884 1025


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(18-218)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 220 a.a.        Molecular weight: 25369.84 Da        Isoelectric Point: 6.0143

>T106012 WP_087537449.1 NZ_CP029610:c2936759-2936100 [Acinetobacter pittii]
MTEREYSESLNPQKALIWRIVHLDNIAWVLEHGLHCGNSLTASPNWVHIGNTELIDKRANHPVPVGQGGYLNDYVPFYFT
PFSPMLLNITTGRGGVRQRSNDEIVILVSSLHRLQELNMPFVFTDGHAYYQWSNFYTDLADLDKIDWQILQKKDFSRDVD
DPAKFERYQAEALVHQHCPIEALLGMICYNEKIKSLLEQQLQQANIEMPVYVRSGVYFK

Download         Length: 660 bp

>T106012 NZ_CP029610:c2936759-2936100 [Acinetobacter pittii]
ATGACAGAACGTGAGTATAGCGAATCTCTCAATCCACAAAAAGCATTGATCTGGAGAATTGTACATCTGGATAATATTGC
TTGGGTTTTGGAACATGGCTTGCACTGTGGCAATAGCCTTACGGCTTCCCCAAATTGGGTACATATTGGTAATACCGAAT
TAATTGATAAAAGAGCAAATCATCCTGTACCAGTTGGACAGGGTGGATACCTGAATGATTATGTACCTTTTTATTTTACG
CCATTTTCTCCCATGCTTTTGAACATCACAACAGGGCGAGGTGGTGTCCGACAGCGTTCTAATGATGAGATTGTCATTCT
CGTATCAAGTCTGCATCGTTTACAGGAATTGAATATGCCGTTTGTATTCACAGATGGTCATGCCTATTATCAATGGTCAA
ATTTCTATACGGATTTAGCTGATTTAGATAAGATTGATTGGCAGATTTTACAGAAAAAAGATTTCAGTCGGGATGTGGAT
GATCCCGCAAAGTTTGAACGTTATCAGGCAGAGGCACTTGTACATCAACATTGTCCGATTGAAGCCCTGCTCGGTATGAT
ATGTTACAATGAGAAAATTAAATCTTTGCTAGAGCAACAATTGCAGCAAGCAAATATTGAAATGCCTGTTTATGTAAGGT
CAGGAGTATATTTTAAATGA

Antitoxin


Download         Length: 355 a.a.        Molecular weight: 40155.14 Da        Isoelectric Point: 5.3205

>AT106012 WP_087537450.1 NZ_CP029610:c2936103-2935039 [Acinetobacter pittii]
MIRYTTGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPDNMAAYRQACKEGRVQTGKMFVTETNEFLAPRWIVNFPTK
QHWKAKSQIEWVEDGLKDLKQFIIEKNISSIAIPPLGAGNGGLDWQDVKPKIESALSDLLDVDVLIFEPTEKYQNIAKNI
GVQKLTPARALIAELIRRYGVLGMECSILEIQKLAWFLQRVIEKHNLSNELRLDFQANYYGPYAHNLTHLLNALDGSYLK
SDKRIPDCEPLDVIWFNQQEQGKVQSYLNSEAKDFVPALEEAAALIEGFESPFGMELLSTVDWLIYKDGCQPTVESIKDG
LANWSAGKRWADRKLSLFKDEHIEYALDKLQKSI

Download         Length: 1065 bp

>AT106012 NZ_CP029610:c2936103-2935039 [Acinetobacter pittii]
ATGATTCGTTATACGACTGGAAACTTACTGGATGCCCCAGTAGAAGCATTGGTCAATACTGTAAATACAGTAGGGGTCAT
GGGGAAAGGCATTGCTTTGATGTTTAAAGAACGATTCCCTGACAATATGGCTGCCTATCGTCAAGCATGTAAAGAGGGGC
GTGTTCAAACAGGAAAAATGTTTGTTACAGAAACCAATGAATTTTTAGCACCTCGCTGGATCGTTAATTTTCCGACTAAA
CAACACTGGAAAGCCAAATCACAAATTGAATGGGTTGAAGATGGGCTGAAAGATTTAAAACAATTTATTATAGAAAAAAA
TATTTCATCTATTGCGATTCCGCCATTGGGTGCTGGTAATGGTGGGTTAGACTGGCAAGATGTAAAGCCAAAAATAGAAT
CTGCATTGTCAGATTTACTGGATGTGGATGTTCTAATTTTTGAACCGACTGAAAAATATCAGAATATTGCAAAAAATATT
GGTGTGCAAAAACTTACACCAGCTCGGGCTTTGATTGCAGAACTGATTCGTAGGTATGGGGTACTGGGTATGGAATGTAG
TATCCTTGAAATCCAAAAGTTAGCATGGTTTCTACAAAGAGTTATCGAAAAACATAATTTATCCAATGAGTTAAGATTGG
ATTTTCAGGCAAACTATTATGGTCCTTACGCCCACAATCTGACACATCTGCTTAATGCACTAGATGGCAGCTATTTAAAG
TCTGACAAAAGAATCCCTGATTGTGAACCATTGGATGTGATTTGGTTTAATCAACAGGAACAAGGCAAAGTACAAAGCTA
TTTGAACAGTGAGGCAAAAGATTTTGTGCCTGCTCTGGAAGAAGCGGCTGCTTTAATTGAGGGGTTTGAATCACCTTTTG
GAATGGAATTGCTTTCTACAGTAGATTGGCTGATCTATAAAGATGGATGTCAGCCAACGGTTGAATCTATTAAAGATGGG
TTAGCAAATTGGTCTGCTGGTAAACGCTGGGCAGATCGGAAGTTATCTTTATTTAAAGATGAACATATTGAGTATGCTTT
GGATAAGTTACAGAAGTCTATTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References