Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2811519..2812195 Replicon chromosome
Accession NZ_CP029610
Organism Acinetobacter pittii strain ST220

Toxin (Protein)


Gene name hicA Uniprot ID A0A829SCE7
Locus tag DLK06_RS13765 Protein ID WP_031968589.1
Coordinates 2812013..2812195 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A829S8Y7
Locus tag DLK06_RS13760 Protein ID WP_031968590.1
Coordinates 2811519..2811923 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLK06_RS13750 2806664..2810713 - 4050 WP_049069247.1 tape measure protein -
DLK06_RS13755 2810838..2811437 - 600 WP_031968591.1 hypothetical protein -
DLK06_RS13760 2811519..2811923 - 405 WP_031968590.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DLK06_RS13765 2812013..2812195 - 183 WP_031968589.1 type II toxin-antitoxin system HicA family toxin Toxin
DLK06_RS13775 2812527..2813060 - 534 WP_032046667.1 hypothetical protein -
DLK06_RS13780 2813107..2814036 - 930 WP_031968587.1 hypothetical protein -
DLK06_RS13785 2814145..2814357 - 213 WP_049069243.1 hypothetical protein -
DLK06_RS13790 2814359..2814757 - 399 WP_049069242.1 prophage PSSB64-02 -
DLK06_RS13795 2814759..2815127 - 369 WP_049069241.1 hypothetical protein -
DLK06_RS13800 2815093..2815506 - 414 WP_049069240.1 hypothetical protein -
DLK06_RS21400 2815518..2815688 - 171 WP_167468861.1 hypothetical protein -
DLK06_RS13805 2815688..2816056 - 369 WP_049069238.1 hypothetical protein -
DLK06_RS13810 2816058..2816447 - 390 WP_049069237.1 hypothetical protein -
DLK06_RS13815 2816452..2817117 - 666 WP_049069236.1 stress-responsive nuclear envelope protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2786847..2842025 55178


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6690.86 Da        Isoelectric Point: 10.7364

>T106011 WP_031968589.1 NZ_CP029610:c2812195-2812013 [Acinetobacter pittii]
VKSLDLIKMIEADGWYQVRVTGSHHHFKHPTKKGLVTVPHPKKDLPSGTVKSILKQAGLH

Download         Length: 183 bp

>T106011 NZ_CP029610:c2812195-2812013 [Acinetobacter pittii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATCAAGTTAGGGTTACAGGAAGTCATCATCACTT
CAAACACCCTACTAAGAAGGGACTGGTTACGGTTCCACATCCTAAAAAGGATTTACCAAGCGGAACTGTTAAAAGCATTT
TGAAACAAGCAGGTCTTCATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.73 Da        Isoelectric Point: 4.3246

>AT106011 WP_031968590.1 NZ_CP029610:c2811923-2811519 [Acinetobacter pittii]
MLYPIAIEMGSDTEAFGVIVPDIPGCHSAGDTLEEALDNIKEAIAGHLEILAEDGEEIPLASSVRKFMDLPEYDGMVWFV
TEVDLGRYLGTPEKINVSLPSRLIRKIDDSVGKDKQYKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT106011 NZ_CP029610:c2811923-2811519 [Acinetobacter pittii]
ATGTTATATCCGATTGCAATTGAAATGGGATCAGATACCGAGGCATTCGGTGTCATCGTTCCTGATATTCCCGGTTGCCA
CAGCGCCGGTGATACCCTCGAAGAAGCTCTCGATAATATTAAAGAAGCGATTGCAGGGCATTTAGAGATTCTTGCTGAAG
ATGGTGAAGAGATTCCTTTAGCATCATCTGTAAGAAAATTTATGGATCTTCCTGAATATGATGGAATGGTTTGGTTCGTA
ACTGAGGTTGATTTAGGCCGTTATCTTGGAACCCCTGAAAAAATCAACGTATCTTTGCCTAGTCGTTTGATTCGTAAGAT
TGATGATAGTGTGGGTAAAGATAAGCAGTATAAAACCCGATCTGCATTTTTGGCTGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829SCE7

Antitoxin

Source ID Structure
AlphaFold DB A0A829S8Y7

References