Detailed information of TA system TA106010

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 477860..478513
• Replicon: chromosome
• Accession: NZ_CP029610
• Organism: Acinetobacter pittii strain ST220

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: DLK06_RS02380
• Protein ID: WP_126117471.1
• Coordinates: 478124..478513 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A009HHW9
• Locus tag: DLK06_RS02375
• Protein ID: WP_002117064.1
• Coordinates: 477860..478117 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DLK06_RS02355	473373..474380	+	1008	WP_002116730.1	DNA-directed RNA polymerase subunit alpha	-
DLK06_RS02360	474399..474776	+	378	WP_002049717.1	50S ribosomal protein L17	-
DLK06_RS02365	474958..476448	+	1491	WP_032057377.1	NAD(P)/FAD-dependent oxidoreductase	-
DLK06_RS02370	476499..477671	-	1173	WP_032057378.1	acyl-CoA dehydrogenase family protein	-
DLK06_RS02375	477860..478117	+	258	WP_002117064.1	succinate dehydrogenase assembly factor 2	Antitoxin
DLK06_RS02380	478124..478513	+	390	WP_126117471.1	hypothetical protein	Toxin
DLK06_RS02385	479284..480372	+	1089	WP_032057381.1	hypothetical protein	-
DLK06_RS02390	480457..481032	+	576	WP_005078319.1	rhombosortase	-
DLK06_RS02395	481212..483422	+	2211	WP_126117472.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15437.54 Da
• Isoelectric Point: 6.2694

>T106010 WP_126117471.1 NZ_CP029610:478124-478513 [Acinetobacter pittii]
MIKELNFELKYSRVSVIFQLFVGLGLAILLYQLLTPIWWLCAVILLFIGFIFFLKQAQISQIEYLDQKLWSVAYFSKKEI
YCGEITKIIDYQLFVVIYLEETPTNIAIVWFDQLPIQQWIRLKVLEKLY

Nucleotide

• Length: 390 bp

>T106010 NZ_CP029610:478124-478513 [Acinetobacter pittii]
TTGATAAAAGAATTAAATTTTGAGCTGAAATATAGCCGTGTCTCGGTAATATTTCAGCTTTTTGTTGGTTTGGGTTTAGC
AATCCTGCTTTATCAATTATTAACACCGATATGGTGGCTATGTGCTGTCATTCTTCTGTTTATTGGTTTTATTTTCTTTC
TAAAGCAAGCACAAATATCTCAAATTGAATATTTAGATCAAAAATTATGGTCGGTTGCATATTTTTCGAAAAAAGAAATT
TACTGTGGGGAAATTACTAAGATAATTGATTATCAGTTGTTTGTGGTTATTTATCTTGAAGAAACTCCTACGAATATAGC
TATTGTTTGGTTCGATCAGCTTCCTATTCAGCAGTGGATAAGATTAAAAGTTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10295.73 Da
• Isoelectric Point: 4.4809

>AT106010 WP_002117064.1 NZ_CP029610:477860-478117 [Acinetobacter pittii]
MSDEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVDQEDPDLLDWFMEVSEPPRTELREFIYKLK
QYVHG

Nucleotide

• Length: 258 bp

>AT106010 NZ_CP029610:477860-478117 [Acinetobacter pittii]
ATGTCTGACGAAATGACCTTGGAAGAACGTAAAGTAATTTATCGAGCACGCCGCGGCTTAAAAGAAATTGACGTCTATTT
TGACCCGTATGTAAAAAATTATTATTTAAAAGCTGATCCGGCTGAAAAAGCATTATTTGCAGAGTTGGTTGATCAAGAAG
ATCCAGATTTATTAGATTGGTTCATGGAAGTTTCTGAACCTCCACGTACTGAGTTACGTGAATTTATTTATAAACTAAAA
CAGTATGTGCATGGCTAA

Structures

Antitoxin

• AlphaFold DB: A0A009HHW9