Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1379348..1380991 Replicon chromosome
Accession NZ_CP029606
Organism Methylibium sp. Pch-M

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag C1M51_RS06520 Protein ID WP_129448756.1
Coordinates 1379348..1380700 (-) Length 451 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag C1M51_RS06525 Protein ID WP_129448757.1
Coordinates 1380707..1380991 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1M51_RS06505 1374808..1375605 - 798 WP_129448753.1 2-oxopent-4-enoate hydratase -
C1M51_RS06510 1375627..1377087 - 1461 WP_129448754.1 2-hydroxymuconic semialdehyde dehydrogenase -
C1M51_RS06515 1377289..1379340 + 2052 WP_129448755.1 EAL domain-containing protein -
C1M51_RS06520 1379348..1380700 - 1353 WP_129448756.1 type II toxin-antitoxin system HipA family toxin Toxin
C1M51_RS06525 1380707..1380991 - 285 WP_129448757.1 helix-turn-helix domain-containing protein Antitoxin
C1M51_RS06535 1381352..1382767 + 1416 WP_129448758.1 class II fumarate hydratase -
C1M51_RS06540 1382776..1383804 - 1029 WP_129448759.1 heat-inducible transcriptional repressor HrcA -
C1M51_RS06545 1383891..1384796 + 906 WP_011830908.1 NAD kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 451 a.a.        Molecular weight: 49664.79 Da        Isoelectric Point: 8.5022

>T106002 WP_129448756.1 NZ_CP029606:c1380700-1379348 [Methylibium sp. Pch-M]
MGRRSHTRRLGLWMNGERVGAWSASPAGDELHYDAGWLRSPRARPLSLSLPFRPGNPPHKGHVVRDYFENLLPDSRPIRE
RLARRFKTATTDAFDLLTEIGRDCVGALQILPEGQDPGDVKVIQALPLDEAGVARALDATIAPSGFDERASDTDEFRISI
AGAQEKTALLWREGRWWRPMGPTPTTHILKLPLGLVGNMKLDLRDSVENEWLCAQVLEAYGLSVARCHPLTFEGQRVLGV
ERFDRLWADDGAWIVRVPQEDMCQATGTPAHAKYEADGGPGIDRILEVLNASRRRVQDRETFFRAQLMFWLMCAPDGHAK
NFSIALHAGGAFSMTPLYDVVSAYPVLGNGPNRISPHRVKLAMALRCTNAHWRMRDILRRHWEAVGRRSGIVSASGQGMD
GLIQDIIDRTPVALDAVAAKLPAGFPAHVADSILNGIAAAVRKLEAAKAS

Download         Length: 1353 bp

>T106002 NZ_CP029606:c1380700-1379348 [Methylibium sp. Pch-M]
ATGGGACGGCGGTCGCACACCCGCAGGCTCGGCTTGTGGATGAACGGCGAGCGGGTGGGAGCCTGGAGTGCCTCGCCCGC
CGGAGACGAGTTGCACTACGACGCGGGCTGGCTGCGCTCGCCGCGGGCGAGGCCGCTGTCCCTGTCCTTGCCGTTCAGAC
CCGGCAATCCGCCTCACAAGGGCCACGTCGTCCGCGACTACTTCGAGAACCTGCTCCCGGACAGCCGACCGATACGTGAA
CGTCTGGCACGCCGGTTCAAGACAGCGACCACAGACGCCTTCGACCTGTTGACCGAGATCGGTCGCGATTGCGTCGGTGC
GCTGCAGATCCTGCCCGAGGGGCAGGACCCCGGCGATGTGAAGGTGATCCAGGCCCTGCCGCTCGACGAGGCCGGCGTGG
CAAGGGCGCTGGATGCCACGATCGCGCCCAGCGGCTTCGACGAACGAGCCTCGGACACGGATGAGTTCCGCATCTCGATC
GCCGGTGCACAGGAGAAGACGGCGCTGCTGTGGCGCGAGGGCCGGTGGTGGCGCCCGATGGGACCGACGCCCACCACACA
CATCCTGAAGTTGCCGCTGGGTCTGGTGGGGAACATGAAGCTCGACCTGCGCGACTCGGTGGAGAACGAATGGCTGTGCG
CCCAGGTGCTGGAGGCCTACGGCTTGTCCGTCGCGCGCTGCCACCCGCTGACGTTCGAGGGCCAGCGCGTCCTCGGCGTC
GAGCGTTTTGACCGGCTGTGGGCAGACGATGGCGCCTGGATCGTTCGCGTGCCGCAGGAAGACATGTGCCAGGCCACCGG
CACGCCGGCACACGCCAAATACGAGGCCGACGGCGGCCCGGGCATCGATCGCATCCTGGAGGTGCTGAACGCCTCGCGTC
GTCGCGTGCAGGACCGGGAGACCTTCTTCCGCGCCCAGCTGATGTTCTGGCTGATGTGCGCACCCGACGGACATGCCAAG
AACTTCAGCATCGCGCTGCACGCGGGCGGTGCCTTCTCGATGACGCCGCTCTACGACGTGGTGTCCGCCTATCCCGTGCT
GGGCAACGGCCCCAACCGGATTTCTCCGCATCGCGTCAAGCTGGCGATGGCGCTGCGGTGCACCAACGCGCACTGGCGCA
TGCGCGACATCCTGCGCCGGCATTGGGAGGCGGTCGGGCGGCGGAGCGGGATCGTGTCCGCGTCGGGGCAGGGCATGGAC
GGGTTGATCCAGGACATCATCGACAGGACCCCCGTCGCATTGGACGCGGTGGCCGCAAAGCTGCCTGCCGGCTTTCCTGC
GCACGTTGCCGACTCGATCTTGAATGGCATTGCTGCCGCCGTGCGCAAGCTCGAGGCGGCGAAGGCCTCGTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10078.66 Da        Isoelectric Point: 11.3760

>AT106002 WP_129448757.1 NZ_CP029606:c1380991-1380707 [Methylibium sp. Pch-M]
MNEFPVRMADQLPSLLQSFRKAAGLTQADVAARLGVTQQTLSALERNASNVGAARLMKLLSILDVELVLRQRRPSGVAAP
RAGGAPGEPDKVQW

Download         Length: 285 bp

>AT106002 NZ_CP029606:c1380991-1380707 [Methylibium sp. Pch-M]
ATGAATGAATTCCCGGTGCGCATGGCGGACCAGCTCCCCAGCCTGCTGCAGAGCTTTCGCAAGGCGGCCGGCCTGACGCA
GGCCGACGTTGCCGCACGGCTCGGTGTCACGCAACAGACGCTGTCTGCGCTCGAACGCAATGCCAGCAACGTCGGTGCGG
CCCGGCTGATGAAGCTGCTCAGCATCCTCGACGTCGAACTCGTGCTGAGGCAGCGACGGCCTTCAGGCGTTGCTGCGCCC
CGGGCGGGCGGTGCACCCGGCGAGCCCGACAAGGTGCAGTGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References