Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 147361..147866 Replicon chromosome
Accession NZ_CP029605
Organism Pseudomonas aeruginosa strain 24Pae112

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag CTT40_RS00665 Protein ID WP_003083773.1
Coordinates 147361..147642 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag CTT40_RS00670 Protein ID WP_003083775.1
Coordinates 147639..147866 (-) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CTT40_RS00640 142612..143961 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
CTT40_RS00645 144010..144696 + 687 WP_003083762.1 FadR family transcriptional regulator -
CTT40_RS00650 144797..145531 + 735 WP_003083764.1 GntR family transcriptional regulator -
CTT40_RS00655 145735..146121 + 387 WP_003083767.1 aegerolysin family protein -
CTT40_RS00660 146153..147061 - 909 WP_003083769.1 LysR family transcriptional regulator -
CTT40_RS00665 147361..147642 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
CTT40_RS00670 147639..147866 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
CTT40_RS00675 148042..148662 - 621 WP_003101226.1 hypothetical protein -
CTT40_RS00680 148763..149263 + 501 WP_003083778.1 LEA type 2 family protein -
CTT40_RS00685 149336..149677 + 342 WP_014603467.1 alkylphosphonate utilization protein -
CTT40_RS00690 149758..151185 - 1428 WP_003083784.1 GABA permease -
CTT40_RS00695 151354..152847 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T105995 WP_003083773.1 NZ_CP029605:c147642-147361 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T105995 NZ_CP029605:c147642-147361 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT105995 WP_003083775.1 NZ_CP029605:c147866-147639 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT105995 NZ_CP029605:c147866-147639 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGATGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6XRW


Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References