Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 5516370..5516934 Replicon chromosome
Accession NZ_CP029601
Organism Streptomyces sp. WAC 01438

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DLM49_RS24595 Protein ID WP_125506483.1
Coordinates 5516587..5516934 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag DLM49_RS24590 Protein ID WP_125506482.1
Coordinates 5516370..5516600 (+) Length 77 a.a.

Genomic Context

DLM49_RS24565DLM49_RS24570DLM49_RS24590DLM49_RS24595DLM49_RS24605DLM49_RS24610DLM49_RS24575DLM49_RS24585DLM49_RS24600
Location: 5511540..5512394 (855 bp)
Type: Others
Protein ID: WP_185930956.1
Location: 5512537..5513055 (519 bp)
Type: Others
Protein ID: WP_125506480.1
Location: 5516370..5516600 (231 bp)
Type: Antitoxin
Protein ID: WP_125506482.1
Location: 5516587..5516934 (348 bp)
Type: Toxin
Protein ID: WP_125506483.1
Location: 5518346..5518885 (540 bp)
Type: Others
Protein ID: WP_125510388.1
Location: 5518869..5519723 (855 bp)
Type: Others
Protein ID: WP_125506485.1
Location: 5513164..5513265 (102 bp)
Type: Others
Protein ID: Protein_4805
Location: 5513600..5516182 (2583 bp)
Type: Others
Protein ID: WP_125506481.1
Location: 5516995..5518011 (1017 bp)
Type: Others
Protein ID: WP_125506484.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DLM49_RS245655511540..5512394+855WP_185930956.1LysR family transcriptional regulator-
DLM49_RS245705512537..5513055+519WP_125506480.1YceI family protein-
DLM49_RS245755513164..5513265-102Protein_4805NADP-dependent oxidoreductase-
DLM49_RS245855513600..5516182-2583WP_125506481.1aminopeptidase N-
DLM49_RS245905516370..5516600+231WP_125506482.1ribbon-helix-helix protein, CopG familyAntitoxin
DLM49_RS245955516587..5516934+348WP_125506483.1type II toxin-antitoxin system PemK/MazF family toxinToxin
DLM49_RS246005516995..5518011-1017WP_125506484.1aspartate-semialdehyde dehydrogenase-
DLM49_RS246055518346..5518885+540WP_125510388.1sigma-70 family RNA polymerase sigma factor-
DLM49_RS246105518869..5519723+855WP_125506485.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-38)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12780.66 Da        Isoelectric Point: 10.5605

>T105991 WP_125506483.1 NZ_CP029601:5516587-5516934 [Streptomyces sp. WAC 01438]
MRRGDIYMVDLEPVRGSEANKVRPAVIVSNDGANESVERNGRGVVSVVPLTSNTTRVLSFQVFLHADESRLPKDSKAQCE
QVRVVAPDRLLHRVGAVPRQRMADIDVALRRHLAL

Download         Length: 348 bp

>T105991 NZ_CP029601:5516587-5516934 [Streptomyces sp. WAC 01438]
ATGAGACGTGGTGACATCTACATGGTGGACCTGGAGCCGGTCAGGGGCAGCGAGGCCAACAAGGTCAGGCCCGCCGTGAT
CGTGTCCAACGACGGTGCCAACGAATCCGTCGAGCGGAACGGCCGCGGCGTCGTGAGCGTCGTGCCGCTGACGTCGAACA
CCACGCGGGTCCTGTCGTTCCAGGTCTTCCTGCACGCCGACGAGAGCCGGCTGCCCAAGGACTCCAAGGCGCAGTGCGAG
CAGGTGCGCGTCGTCGCGCCGGACCGGCTGCTGCACCGGGTCGGTGCCGTCCCCCGGCAGCGGATGGCCGACATCGACGT
GGCGCTGCGGCGGCACCTGGCGCTCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8491.18 Da        Isoelectric Point: 3.7615

>AT105991 WP_125506482.1 NZ_CP029601:5516370-5516600 [Streptomyces sp. WAC 01438]
MKISVSLPQEDVAFVDEYAERTEAESRSAVIHAAIELLRQAQLVQEYTEAFAEWDAGEDAAAWDRTSGDGITDETW

Download         Length: 231 bp

>AT105991 NZ_CP029601:5516370-5516600 [Streptomyces sp. WAC 01438]
ATGAAGATCAGTGTGAGTCTGCCTCAGGAGGATGTCGCCTTCGTCGACGAGTACGCCGAGCGCACGGAGGCCGAATCCAG
GTCGGCCGTGATACACGCCGCGATCGAGCTGCTGCGGCAGGCGCAACTCGTACAGGAGTACACCGAGGCGTTCGCCGAGT
GGGACGCGGGCGAGGACGCCGCCGCCTGGGACCGGACGAGCGGGGACGGGATCACCGATGAGACGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References