Detailed information of TA system TA105991

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 5516370..5516934
• Replicon: chromosome
• Accession: NZ_CP029601
• Organism: Streptomyces sp. WAC 01438

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: DLM49_RS24595
• Protein ID: WP_125506483.1
• Coordinates: 5516587..5516934 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: DLM49_RS24590
• Protein ID: WP_125506482.1
• Coordinates: 5516370..5516600 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DLM49_RS24565	5511540..5512394	+	855	WP_185930956.1	LysR family transcriptional regulator	-
DLM49_RS24570	5512537..5513055	+	519	WP_125506480.1	YceI family protein	-
DLM49_RS24575	5513164..5513265	-	102	Protein_4805	NADP-dependent oxidoreductase	-
DLM49_RS24585	5513600..5516182	-	2583	WP_125506481.1	aminopeptidase N	-
DLM49_RS24590	5516370..5516600	+	231	WP_125506482.1	ribbon-helix-helix protein, CopG family	Antitoxin
DLM49_RS24595	5516587..5516934	+	348	WP_125506483.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
DLM49_RS24600	5516995..5518011	-	1017	WP_125506484.1	aspartate-semialdehyde dehydrogenase	-
DLM49_RS24605	5518346..5518885	+	540	WP_125510388.1	sigma-70 family RNA polymerase sigma factor	-
DLM49_RS24610	5518869..5519723	+	855	WP_125506485.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-115)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-38)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12780.66 Da
• Isoelectric Point: 10.5605

>T105991 WP_125506483.1 NZ_CP029601:5516587-5516934 [Streptomyces sp. WAC 01438]
MRRGDIYMVDLEPVRGSEANKVRPAVIVSNDGANESVERNGRGVVSVVPLTSNTTRVLSFQVFLHADESRLPKDSKAQCE
QVRVVAPDRLLHRVGAVPRQRMADIDVALRRHLAL

Nucleotide

• Length: 348 bp

>T105991 NZ_CP029601:5516587-5516934 [Streptomyces sp. WAC 01438]
ATGAGACGTGGTGACATCTACATGGTGGACCTGGAGCCGGTCAGGGGCAGCGAGGCCAACAAGGTCAGGCCCGCCGTGAT
CGTGTCCAACGACGGTGCCAACGAATCCGTCGAGCGGAACGGCCGCGGCGTCGTGAGCGTCGTGCCGCTGACGTCGAACA
CCACGCGGGTCCTGTCGTTCCAGGTCTTCCTGCACGCCGACGAGAGCCGGCTGCCCAAGGACTCCAAGGCGCAGTGCGAG
CAGGTGCGCGTCGTCGCGCCGGACCGGCTGCTGCACCGGGTCGGTGCCGTCCCCCGGCAGCGGATGGCCGACATCGACGT
GGCGCTGCGGCGGCACCTGGCGCTCTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8491.18 Da
• Isoelectric Point: 3.7615

>AT105991 WP_125506482.1 NZ_CP029601:5516370-5516600 [Streptomyces sp. WAC 01438]
MKISVSLPQEDVAFVDEYAERTEAESRSAVIHAAIELLRQAQLVQEYTEAFAEWDAGEDAAAWDRTSGDGITDETW

Nucleotide

• Length: 231 bp

>AT105991 NZ_CP029601:5516370-5516600 [Streptomyces sp. WAC 01438]
ATGAAGATCAGTGTGAGTCTGCCTCAGGAGGATGTCGCCTTCGTCGACGAGTACGCCGAGCGCACGGAGGCCGAATCCAG
GTCGGCCGTGATACACGCCGCGATCGAGCTGCTGCGGCAGGCGCAACTCGTACAGGAGTACACCGAGGCGTTCGCCGAGT
GGGACGCGGGCGAGGACGCCGCCGCCTGGGACCGGACGAGCGGGGACGGGATCACCGATGAGACGTGGTGA