Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 3170185..3170717 Replicon chromosome
Accession NZ_CP029601
Organism Streptomyces sp. WAC 01438

Toxin (Protein)


Gene name relE Uniprot ID A0A429AE17
Locus tag DLM49_RS13860 Protein ID WP_030861082.1
Coordinates 3170185..3170442 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag DLM49_RS13865 Protein ID WP_125504689.1
Coordinates 3170439..3170717 (-) Length 93 a.a.

Genomic Context

DLM49_RS13830DLM49_RS13835DLM49_RS13845DLM49_RS37045DLM49_RS13855DLM49_RS13870DLM49_RS13880DLM49_RS13840DLM49_RS13860DLM49_RS13865DLM49_RS13875DLM49_RS36660
Location: 3166191..3167699 (1509 bp)
Type: Others
Protein ID: WP_125510104.1
Location: 3167789..3168058 (270 bp)
Type: Others
Protein ID: WP_185930927.1
Location: 3168505..3169122 (618 bp)
Type: Others
Protein ID: WP_125504687.1
Location: 3169167..3169568 (402 bp)
Type: Others
Protein ID: WP_185930926.1
Location: 3169721..3170191 (471 bp)
Type: Others
Protein ID: WP_125504688.1
Location: 3171166..3171861 (696 bp)
Type: Others
Protein ID: WP_185930925.1
Location: 3172681..3173634 (954 bp)
Type: Others
Protein ID: WP_125504691.1
Location: 3168122..3168328 (207 bp)
Type: Others
Protein ID: Protein_2727
Location: 3170185..3170442 (258 bp)
Type: Toxin
Protein ID: WP_030861082.1
Location: 3170439..3170717 (279 bp)
Type: Antitoxin
Protein ID: WP_125504689.1
Location: 3172040..3172594 (555 bp)
Type: Others
Protein ID: WP_125504690.1
Location: 3173691..3174725 (1035 bp)
Type: Others
Protein ID: WP_164555632.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DLM49_RS138303166191..3167699+1509WP_125510104.1ISL3 family transposase-
DLM49_RS138353167789..3168058+270WP_185930927.1hypothetical protein-
DLM49_RS138403168122..3168328-207Protein_2727hypothetical protein-
DLM49_RS138453168505..3169122+618WP_125504687.1hypothetical protein-
DLM49_RS370453169167..3169568+402WP_185930926.1hypothetical protein-
DLM49_RS138553169721..3170191+471WP_125504688.1ATP-binding protein-
DLM49_RS138603170185..3170442-258WP_030861082.1Txe/YoeB family addiction module toxinToxin
DLM49_RS138653170439..3170717-279WP_125504689.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
DLM49_RS138703171166..3171861+696WP_185930925.1hypothetical protein-
DLM49_RS138753172040..3172594-555WP_125504690.1TetR/AcrR family transcriptional regulator-
DLM49_RS138803172681..3173634+954WP_125504691.1alpha/beta hydrolase-
DLM49_RS366603173691..3174725-1035WP_164555632.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--3166188..31676991511


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-69)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10245.82 Da        Isoelectric Point: 10.1554

>T105989 WP_030861082.1 NZ_CP029601:c3170442-3170185 [Streptomyces sp. WAC 01438]
VRDVRFRPTGWEDLLYWQAADKKLFRKLIRLIGEIQRDPFTGIGKPEPLKGDLSGYWSRRIDDEHRLVYRATEKEVVIIK
ARYHY

Download         Length: 258 bp

>T105989 NZ_CP029601:c3170442-3170185 [Streptomyces sp. WAC 01438]
GTGAGGGATGTACGGTTCCGCCCCACCGGGTGGGAGGACCTCCTGTACTGGCAGGCCGCCGACAAGAAGCTGTTCCGCAA
GCTCATCCGTCTGATCGGCGAGATCCAGCGCGACCCCTTCACCGGTATCGGTAAACCGGAACCGCTGAAGGGCGACCTGT
CGGGGTACTGGTCACGCCGGATCGACGACGAGCACCGCCTCGTCTACCGGGCCACCGAGAAGGAAGTCGTGATCATCAAG
GCCCGGTACCACTACTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9956.10 Da        Isoelectric Point: 4.1348

>AT105989 WP_125504689.1 NZ_CP029601:c3170717-3170439 [Streptomyces sp. WAC 01438]
MSITASEARARLFPLIQQVNDDHEPVEITSRGGDAVLMSADDFRSWQETVYLLRSPANAAHLMAAVAADRAADTPVITRS
MAELEALAEDGE

Download         Length: 279 bp

>AT105989 NZ_CP029601:c3170717-3170439 [Streptomyces sp. WAC 01438]
ATGTCCATCACTGCCAGCGAGGCCCGGGCCAGGCTTTTCCCGCTGATCCAGCAGGTCAACGACGACCATGAGCCCGTGGA
GATCACCTCCAGGGGCGGCGACGCCGTACTGATGTCGGCCGACGACTTCCGTTCCTGGCAGGAGACGGTCTACCTGCTGC
GCTCGCCGGCCAACGCCGCCCACCTCATGGCGGCCGTCGCCGCGGACAGGGCCGCCGACACCCCGGTGATCACCAGGAGC
ATGGCGGAGCTGGAGGCCCTGGCGGAGGACGGCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A429AE17

Antitoxin

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Source
ID
Structure
No matching records found

References