Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2939531..2940188 Replicon chromosome
Accession NZ_CP029597
Organism Klebsiella quasipneumoniae subsp. similipneumoniae strain ATCC 700603

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag DLJ73_RS14740 Protein ID WP_004205323.1
Coordinates 2939778..2940188 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag DLJ73_RS14735 Protein ID WP_002916312.1
Coordinates 2939531..2939797 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLJ73_RS14710 2934682..2936115 - 1434 WP_004205314.1 6-phospho-beta-glucosidase BglA -
DLJ73_RS14715 2936234..2936962 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
DLJ73_RS14720 2937012..2937323 + 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
DLJ73_RS14725 2937486..2938145 + 660 WP_004205319.1 hemolysin III family protein -
DLJ73_RS14730 2938302..2939285 - 984 WP_004205321.1 tRNA-modifying protein YgfZ -
DLJ73_RS14735 2939531..2939797 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
DLJ73_RS14740 2939778..2940188 + 411 WP_004205323.1 protein YgfX Toxin
DLJ73_RS14745 2940195..2940716 - 522 WP_004205324.1 flavodoxin FldB -
DLJ73_RS14750 2940817..2941713 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
DLJ73_RS14755 2941736..2942449 + 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DLJ73_RS14760 2942455..2944188 + 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T105977 WP_004205323.1 NZ_CP029597:2939778-2940188 [Klebsiella quasipneumoniae subsp. similipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T105977 NZ_CP029597:2939778-2940188 [Klebsiella quasipneumoniae subsp. similipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCTCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GACTGGGAGATCCTCGGGACGCCGTGGGTCATCAACAGCGGAATGCTGCTGCGTTTGCGCCATGTCGATACCCGACGCGG
TCAGCATCTGTGGCTGGCGGCGGACAGCATGGATGCCGGAGAGTGGCGGGACCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT105977 WP_002916312.1 NZ_CP029597:2939531-2939797 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT105977 NZ_CP029597:2939531-2939797 [Klebsiella quasipneumoniae subsp. similipneumoniae]
ATGGACATTAACAATAAAGCTCGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TATTCAACTGGCTGATGAACCATGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References