Detailed information of TA system TA105976

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 1604233..1604749
• Replicon: chromosome
• Accession: NZ_CP029597
• Organism: Klebsiella quasipneumoniae subsp. similipneumoniae strain ATCC 700603

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DLJ73_RS07965
• Protein ID: WP_004206511.1
• Coordinates: 1604233..1604517 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: DLJ73_RS07970
• Protein ID: WP_002886901.1
• Coordinates: 1604507..1604749 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DLJ73_RS07950	1599275..1600930	+	1656	WP_004206514.1	alpha,alpha-phosphotrehalase	-
DLJ73_RS07955	1601316..1603454	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
DLJ73_RS07960	1603765..1604229	+	465	WP_004206512.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
DLJ73_RS07965	1604233..1604517	-	285	WP_004206511.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DLJ73_RS07970	1604507..1604749	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DLJ73_RS07975	1604827..1606737	-	1911	WP_004206509.1	BglG family transcription antiterminator	-
DLJ73_RS07980	1606760..1607911	-	1152	WP_004206508.1	lactonase family protein	-
DLJ73_RS07985	1607979..1608719	-	741	WP_004206507.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11163.01 Da
• Isoelectric Point: 10.4599

>T105976 WP_004206511.1 NZ_CP029597:c1604517-1604233 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MTYELEFDPRAWREWQKLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCDKIKLKASGYRLVYQVRDRVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T105976 NZ_CP029597:c1604517-1604233 [Klebsiella quasipneumoniae subsp. similipneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCTTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTGCCGGATTGCGACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGCTGGTGTATCAAGTACGAGATAGGGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT105976 WP_002886901.1 NZ_CP029597:c1604749-1604507 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT105976 NZ_CP029597:c1604749-1604507 [Klebsiella quasipneumoniae subsp. similipneumoniae]
ATGGCCACGCTCAACGTTCGGCTGGATGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACGCC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGCGATG
GCGAAGCGGCGTTGTTACGCACCGTTCGCGAGCGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0