Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 878588..879207 Replicon chromosome
Accession NZ_CP029597
Organism Klebsiella quasipneumoniae subsp. similipneumoniae strain ATCC 700603

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag DLJ73_RS04420 Protein ID WP_002892050.1
Coordinates 878989..879207 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag DLJ73_RS04415 Protein ID WP_002892066.1
Coordinates 878588..878962 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLJ73_RS04405 873741..874934 + 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DLJ73_RS04410 874957..878103 + 3147 WP_004204748.1 multidrug efflux RND transporter permease subunit -
DLJ73_RS04415 878588..878962 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
DLJ73_RS04420 878989..879207 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
DLJ73_RS04425 879366..879932 + 567 WP_004204750.1 maltose O-acetyltransferase -
DLJ73_RS28040 879904..880026 - 123 WP_032426076.1 hypothetical protein -
DLJ73_RS04430 880069..880539 + 471 WP_004204751.1 YlaC family protein -
DLJ73_RS04435 880508..881965 - 1458 WP_004204752.1 PLP-dependent aminotransferase family protein -
DLJ73_RS04440 882066..882764 + 699 WP_004204753.1 GNAT family N-acetyltransferase -
DLJ73_RS04445 882761..882901 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
DLJ73_RS04450 882901..883164 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T105975 WP_002892050.1 NZ_CP029597:878989-879207 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T105975 NZ_CP029597:878989-879207 [Klebsiella quasipneumoniae subsp. similipneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAACAAATATGAACTTTCTGATAATGAGCTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACTATGAATAAGCTGTACGATAAAATCCCGACGTCCGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT105975 WP_002892066.1 NZ_CP029597:878588-878962 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT105975 NZ_CP029597:878588-878962 [Klebsiella quasipneumoniae subsp. similipneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCACAACTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACATCGGCTGTCAATCTCCAGTTAAATGAACTGATCGAGC
ACATTGCCACATTCGCCCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACATTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGGTT
ATTTCGTTGTTTTGTCAACGCCAGCCGGGAAAATCCGGCCAGTCTTTCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References